BOC-N-メチル-L-ロイシン
BOC-N-メチル-L-ロイシン 物理性質
- 融点 :
- 55-60 °C
- 沸点 :
- 338.2±21.0 °C(Predicted)
- 比重(密度) :
- 1.053±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 酸解離定数(Pka):
- 4.04±0.21(Predicted)
- 外見 :
- Solid
- 色:
- White to off-white
- 光学活性 (optical activity):
- [α]20/D 36±2°, c = 1% in methylene chloride
- BRN :
- 2373250
- InChI:
- InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
- InChIKey:
- YXJFAOXATCRIKU-VIFPVBQESA-N
- SMILES:
- C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
- CAS データベース:
- 53363-89-6(CAS DataBase Reference)
BOC-N-メチル-L-ロイシン 価格
もっと(13)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBSS-8078 |
Boc-N-メチル-L-ロイシン
Boc-N-methyl-L-leucine |
53363-89-6 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBSS-8078 |
Boc-N-メチル-L-ロイシン
Boc-N-methyl-L-leucine |
53363-89-6 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBSS-8078 |
Boc-N-methyl-L-leucine |
53363-89-6 |
10g |
￥16000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS042438 |
Boc-Nalpha-methyl-L-leucine |
53363-89-6 |
5g |
￥100700 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01MAS042438 |
Boc-Nalpha-methyl-L-leucine |
53363-89-6 |
1g |
￥25300 |
2024-03-01 |
購入 |
BOC-N-メチル-L-ロイシン 化学特性,用途語,生産方法
説明
Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.
生物活性
Boc-N-methyl-L-leucine is a peptidyl nucleobase that has been shown to inhibit tumor cell growth and induce tumor regression in animal models. It is an amide of leucine and the antibiotic aminouracil, which is a guanine analogue. Boc-N-methyl-L-leucine has also shown to inhibit tumor growth by inhibiting mitochondrial membrane potential, which may lead to cell death in cancer cells. This compound has been shown to be effective against both solid tumors and leukemia cell lines. Boc-N-methyl-L-leucine also inhibits the proliferation of human prostate cancer cells by blocking the synthesis of nucleic acids and proteins.
参考文献
https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay
BOC-N-メチル-L-ロイシン 上流と下流の製品情報
原材料
準備製品
BOC-N-メチル-L-ロイシン 生産企業
Global( 176)Suppliers
BOC-N-メチル-L-ロイシン スペクトルデータ(MS)
53363-89-6(BOC-N-メチル-L-ロイシン)キーワード:
- 53363-89-6
- N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
- N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
- N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE
- N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE
- N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
- N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE
- BOC-BETA-TBU-ALANINE
- BOC-BETA-TBU-ALA-OH
- BOC-BETA-T-BUTYL-L-ALANINE
- BOC-ALA(TBU)-OH
- BOC-N-ME-LEUCINE
- BOC-N-ME-LEU-OH
- BOC-N-METHYL-L-LEUCINE
- BOC-N-METHYL-L-LEU-OH
- BOC-MELEU-OH
- BOC-NEOPENTYLGLYCINE
- BOC-(NEOPENTYL)GLY-OH
- BOC-N-ALPHA-METHYL-L-LEUCINE
- BOC-L-BETA-T-BUTYLALANINE
- BOC-LEU(ME)-OH
- BOC-L-NEOPENTYLGLYCINE
- BOC-L-MELEU-OH
- BOC-T-BUTYL-L-ALANINE
- N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-LEUCINE
- DANSYL-L-GLUTAMIC ACID BIS(CYCLOHEXYLAMMONIUM)
- NALPHA-tert-Butoxycarbonyl-N-methyl-L-leucine
- N-tert-Butyloxycarbonyl-N-methyl-L-leucine
- N-(tert-butoxycarbonyl)-N-methyl-L-leucine
- L-Leucine, N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl-
- (S)-2-((tert-butoxycarbonyl)(Methyl)aMino)-4-Methylpentanoic acid
- BOC-N-メチル-L-ロイシン