KL001
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- CAS番号.
- 309928-48-1
- 化学名:
- 别名:
- 英語名:
- KL001
- 英語别名:
- KL001(KL-001;N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide;N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide;Methanesulfonamide, N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-;Inhibitor,inhibit,stabilizer,KL001,circadian,cryptochrome,ubiquitin,period,gluconeogenesis,CRY
- CBNumber:
- CB32695946
- 化学式:
- C21H22N2O4S
- 分子量:
- 398.48
- MOL File:
- 309928-48-1.mol
- MSDS File:
- SDS
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KL001 物理性質
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：可溶20mg/mL、透明
- 外見 :
- 粉
- 色:
- 白からベージュ
- 安定性：:
- DMSO溶液またはエタノール溶液で-20°Cで最大3か月保存できます。
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
Xn |
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| Rフレーズ |
22 |
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| WGK Germany |
3 |
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| 絵表示（GHS） |
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| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
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| 注意書き |
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| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC4685 |
KL 001 |
309928-48-1 |
10mg |
￥66000 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC4685 |
KL 001 |
309928-48-1 |
50mg |
￥272000 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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SML1032 |
≥98% (HPLC)
KL001 ≥98% (HPLC) |
309928-48-1 |
5mg |
￥17400 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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SML1032 |
≥98% (HPLC)
KL001 ≥98% (HPLC) |
309928-48-1 |
25mg |
￥70400 |
2024-03-01 |
購入 |
KL001 化学特性,用途語,生産方法
使用
KL001 is a small molecule that specifically interacts with cryptochrome (CRY). KL001 prevented ubiquitin-dependent degrdation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes making it a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
Biochem/physiol Actions
KL001 stabilizes cryptochrome (CRY), preventing ubiquitin-dependent degradation. CRY proteins are part of a feedback loop, acting as transcription repressors to inhibit CLOCK-BMAL1 components of the circadian clock. KL001 stabilization of CRY proteins results in lengthening of the circadian period, and also inhibited glucagon-induced gluconeogenesis in primary hepatocytes. Other compounds affecting circadian rhythms include Casein kinase I (CKI) inhibitors such as longdaysin (Sigma Prod. No. SML0127) and synthetic ligands for the nuclear receptors REV-ERB such as SR8278 (Sigma Prod. No. S9576), but KL001 appears to be the first small molecule that specifically acts on CRY proteins.
KL001 上流と下流の製品情報
原材料
準備製品
KL001 生産企業
Global( 47)Suppliers
309928-48-1()キーワード:
- 309928-48-1
- N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide
- N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide
- Methanesulfonamide, N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-
- KL001(KL-001
- Inhibitor,inhibit,stabilizer,KL001,circadian,cryptochrome,ubiquitin,period,gluconeogenesis,CRY