プロジギオシン 塩酸塩 化学特性,用途語,生産方法
一般的な説明
Prodigiosin is a red pigment with common pyrrolyl pyrromethene skeleton and is biosynthesized by
Serratia marcescens and other bacteria.
Biochem/physiol Actions
Prodigiosin, a tripyrrole red pigment biosynthesized by Serratia marcescens and other bacteria, exhibits antibacterial, anticancer, cytotoxic, immunosuppressive, and antiproliferative activities. Prodigiosin induces apoptosis in hematopoietic cancer cells and cells derived from other human cancers, including gastric and colon with no marked toxicity in nonmalignant cell lines. Morphological analysis of prodigiosin-treated cells demonstrated that prodigiosin induces cell shrinkage, chromatin condensation, reorganization of actin microfilament architecture, and detachment of cells from the cell culture substrate. Different targets and mechanisms of action are described for prodigiosin, including induction of single- and double-strand DNA breaks, modulation of pH, regulation of mitogen-activated protein kinase, and inhibition of cell cycle progression.
プロジギオシン 塩酸塩 上流と下流の製品情報
原材料
準備製品