ANTI-CASK/LIN2 (KA-17) 化学特性,用途語,生産方法
使用
Anti-CASK/LIN2 (KA-17) antibody produced in rabbit is suitable for:
- immunoprecipitation at a concentraqtion of 5-10μg, using lysate of 3x105 cultured MDCK cells
- western blot (chemiluminescent) at a dilution of 1:300, using whole cell extract of cultured human Jurkat and dog MDCK kidney cells
一般的な説明
Calcium/Calmodulin-dependent Serine Kinase (CASK/Lin-2) is predominant in the brain, may be ubiquitously expressed. It localizes to the lateral and/or basal plasma membrane regions in epithelial cells.
Biochem/physiol Actions
CASK/Lin-2 (Calcium/Calmodulin-dependent Serine Kinase) is translocated into the nucleus to regulate gene expression. It interacts via its PDZ domain with the cytosolic tail of the transmembrane cell surface heparin sulfate proteoglycan Syndecan-2. In neurons it interacts with neurexins. In addition, CASK/Lin-2 is capable of interacting with the actinbinding band 1 protein, neuronal munc18-1-interacting protein 1(Mint-1/Lin-10), protein lin-7 homolog A (Veli/Lin-7) proteins, junctional adhesion molecule (JAM), disks large homolog 1 (hDlg), and the nuclear T-box brain transcription factor 1 (Tbr-1).
ANTI-CASK/LIN2 (KA-17) 上流と下流の製品情報
原材料
準備製品