Autotaxin Inhibitor II, HA130 - Calbiochem 化学特性,用途語,生産方法
一般的な説明
A thiazolidinedione that is designed to target the ATX active site thr210 with a boronic moiety and shown to potently inhibit ATX lysoPLD activity (IC
50 ~28 nM using recombinant human ATX or human plasma) in a reversible manner with a mixed-type Lineweaver-Burk kinetics. Reported to exhibit low cytotoxicity (TD
50 = 83, 105, and 2056 μM in HEK293T, A2058, and HepG2 cultures) and no activity toward NPP1, PDE, AP, or proteasomal chymotryptic/tryptic/caspase-like activities even at concentrations as high as 10 μM. Although HA130 quickly and effectively reduces circulating LPA level when injected in mice (463 μg/kg, i.v.)
in vivo, the effect appears short-lived as is the case with S32826 (Cat. No.189510).
Autotaxin Inhibitor II, HA130 - Calbiochem 上流と下流の製品情報
原材料
準備製品