ビタミン K1 化学特性,用途語,生産方法
外観
黄色～赤みの黄色, 澄明の液体
性質
黄色液体．mp. -20 °C．λmax 243，249 nm，ε 18600，260 (ヘキサン)．空気には比較的安定．光で分解．希酸安定．塩基・還元剤で分解
定義
本品は、次の化学式で表されるナフトキノン誘導体である。
溶解性
水に不溶, エタノール, エーテルに可溶。
解説
フィチル基(フィトールの炭素骨格部分)がメチルナフトキノンに結合した化合物．ビタミンK
1．緑葉に多く含まれ，血液凝固を促進する．
用途
HPLCによるビタミンK1測定用標準品。
生物学的性質
欠乏症：血液中プロトロンビンの濃度低下，血液凝固時間延長による出血 機能：多くのグラム陰性菌で中間電子伝達体．メナジオン(K3，2-メチル-1, 4-ナフトキノン)も同様の作用
用途
ビタミン K1 化合物です。
化粧品の成分用途
皮膚コンディショニング剤
効能
低プロトロンビン血症治療薬, 止血薬, ビタミンK1補充薬
商品名
カチーフ (日本製薬); ケーワン (エーザイ)
説明
Vitamin K
1 is a fat-soluble, dietary nutrient that is essential for the synthesis of proteins important for blood-clotting, bone metabolism, and cell growth. It is found in the photosynthetic tissues of green, leafy plants, where it acts as an electron acceptor forming part of the electron transport chain of Photosystem I. Vitamin K
1 also serves as a precursor to vitamin K
2 and is reported to exhibit anticancer activity in various cell lines.
化学的特性
Yellow Oil
分布
緑草に多い
使用
vitamin K1
一般的な説明
Vitamin K
1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin.
職業ばく露
Phylloquinone is a dietary component essential for normal biosynthesis of several factors required for clotting of blood; as a therapeutic drug used to correct bleeding tendency; and as a food supplement.
輸送方法
UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
純化方法
Vitamin K1 is a yellow viscous oil, which can be distilled at high vacuum practically unchanged. It is insoluble in H2O, but soluble in common organic solvents. Store it in the dark under N2 as it is oxygen sensitive. It has 1cm 328 at 248nm. [Fieser et al. J Am Chem Soc 61 2557 1939, Hirschmann et al. J Am Chem Soc 76 4592 1954, Isler & Doebel Helv Chim Acta 27 225 1954, Beilstein 7 IV 2496.]
不和合性
Phylloquinone is photosensitive; decomposes in sunlight and is destroyed by alkali hydroxides and reducing agents such as hydrideds and active metals. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
廃棄物の処理
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
ビタミン K1 上流と下流の製品情報
原材料
準備製品