イロプロスト 化学特性,用途語,生産方法
効能
血圧降下薬, 血小板凝集抑制薬, プロスタグランジンI2受容体作動薬
商品名
ベンテイビス (バイエル薬品)
説明
Iloprost is a stable epoprostenol derivative which acts as an inhibitor of platelet
aggregation and is recommended for the treatment of peripheral vascular diseases. The
compound was shown to be a potent agonist at PGE
2-sensitive and
prostacyclin-sensitive receptors in animal studies. Iloprost is administered by IV
infusion and has been reported to have beneficial effects in Buerger's and Raynaud's
diseases as well as peripheral artery occlusive disease.
化学的特性
Colourless Oil
定義
ChEBI: A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R
/stereo>)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension.
健康ハザード
Exposures to quinine vapor are highly irritating to the eyes and may be followed by corneal
opacities, structural changes in the cornea, and loss of vision. Solid quinone may
produce discoloration, severe irritation, swelling, and form papules and vesicles.
生物活性
Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively).
イロプロスト 上流と下流の製品情報
原材料
準備製品