BDNF (Brain-derived Neurotrophin factor) 化学特性,用途語,生産方法
解説
2個以上のアミノ酸分子が，相互にカルボキシル基とアミノ基とのあいだの酸アミド結合(ペプチド結合－CO－NH－)によって結合した化合物．結合したアミノ酸残基の数によって，ジペプチド，トリペプチドなどという．低分子量のポリペプチドは合成によってつくられるが，アミノ酸残基数が10個以上のペプチドは天然に存在し，成長ホルモン放出抑制因子のソマトスタチン，副腎皮質刺激ホルモンなどがある．50以上のものを一般にタンパク質という．
一般的な説明
The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM
Biochem/physiol Actions
The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.
BDNF (Brain-derived Neurotrophin factor) 上流と下流の製品情報
原材料
準備製品