(R,R)-1,2,4,5-Diepoxypentane 化学特性,用途語,生産方法
合成
The original procedure utilizes a reversible acyl transfer reaction of acetylacetone (1) using aluminum trichloride and chloroacetyl chloride. The reaction is driven forward through removal of acetyl chloride by distillation and the resulting dichlorodione is isolated (57–58% yield) as copper complex 2. The dione is then liberated from the metal under acidic conditions and subjected to Noyori asymmetric hydrogenation5–9 under high pressure to give dichlorodiol R,R-3 in 40% yield after recrystallization, which undergoes double cyclization under basic conditions to form bis-epoxide R,R-4 (92% yield; >97% ee).
(R,R)-1,2,4,5-Diepoxypentane 上流と下流の製品情報
原材料
準備製品