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[14C]イパモレリン

[14C]イパモレリン 化学構造式
170851-70-4
CAS番号.
170851-70-4
化学名:
[14C]イパモレリン
别名:
α-(1-14C)-Aib-His-N-[2-アミノ-3-(2-ナフチル)プロピオニル]-D-Phe-Lys-NH2;[14C]イパモレリン;(2S)-6-アミノ-2-[(2R)-2-{2-アミノ-N-[(2S)-2,4-ジアミノ-2-[(1H-イミダゾール-4-イル)メチル]-4-メチル-3-オキソ(3-14C)ペンタノイル]-3-(ナフタレン-2-イル)プロパンアミド}-3-フェニルプロパンアミド]ヘキサンアミド
英語名:
Ipamorelin
英語别名:
IpaMorelin Acetate;lpamorelin;Ipamoreli;Aib-His-D-2-Nal-D-Phe-Lys-NH2;IpoMarelin;IPAMORELIN;NNC-26-0161;IPAMOREILIN;Iparmorelin;Ipamorelin IPA
CBNumber:
CB41117534
化学式:
C38H49N9O5
分子量:
711.85
MOL File:
170851-70-4.mol

[14C]イパモレリン 物理性質

融点 :
144-147°C
沸点 :
1185.5±65.0 °C(Predicted)
比重(密度) :
1.263±0.06 g/cm3(Predicted)
貯蔵温度 :
-20°C Freezer
溶解性:
アセトニトリル（微量、加温）、メタノール（微量）、水（微量）
酸解離定数(Pka):
13.04±0.46(Predicted)
外見 :
個体
色:
ホワイトからオフホワイト
InChIKey:
NEHWBYHLYZGBNO-BVEPWEIPSA-N
SMILES:
C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@@H](CC1=CC=C2C(=C1)C=CC=C2)NC(=O)[C@H](CC1N=CNC=1)NC(=O)[C@](C)(C)N

安全性情報

[14C]イパモレリン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan SML1322 ≥98%
Ipamorelin acetate ≥98%		 170851-70-4 10MG ￥13400 2024-03-01 購入
Sigma-Aldrich Japan SML1322 ≥98%
Ipamorelin acetate ≥98%		 170851-70-4 50MG ￥67600 2024-03-01 購入

[14C]イパモレリン 化学特性,用途語,生産方法

説明

Ipamorelin (INN) (developmental code name NNC 26-0161) is a peptide selective agonist of the ghrelin/growth hormone secretagogue receptor (GHS) and a growth hormone secretagogue.It is a pentapeptide with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 that was derived from GHRP-1.

使用

Ipamorelin was originally developed by Novo Nordisk, and was investigated in phase II clinical trials by Helsinn Therapeutics for the treatment of postoperative ileus, but was discontinued due to lack of efficacy.Ipamorelin has been used by athletes as a performance enhancing drug.

Biochem/physiol Actions

Ipamorelin is a highly selective, potent pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and gastrin mimetic with growth hormone (GH) releasing activity. It mimics gastrin and binds to the gastrin receptor (or growth hormone secretion receptor, GHSR) in the brain, which selectively stimulates the pituitary gland to release growth hormone. This leads to elevated plasma GH levels, which affects many biological processes. In addition to being found in the brain, GHSR is found in the gastrointestinal tract, heart, lungs, liver, kidneys, pancreas, adipose tissue and immune cells. Unlike other growth hormone releasing peptides, ipamorelin stimulates the release of growth hormone only in a manner very similar to that of growth hormone releasing hormone[1].

副作用

Ipamorelin is generally considered safe and well tolerated, with common side effects including dizziness, headache, nausea, diarrhoea and flushing. Allergic or serious adverse reactions are rare.

合成

Ipamorelin was prepared from a total of 4.53 g of the peptide resin Boc-Aib-His (Trt)-D-2Nal-DPhe-Lys (Boc)-NH-resin according to the Fmoc strategy on an Applied Biosystems 431A peptide synthesizer in two identical runs (to obtain sufficient material) in 1 mmol scale using the FastMoc UV protocols supplied by the manufacturer, that employ HBTU mediated couplings in NMP and UV monitoring of the deprotection of the Fmoc protection group.

[14C]イパモレリン 上流と下流の製品情報

原材料

準備製品

[14C]イパモレリン 生産企業

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170851-70-4([14C]イパモレリン)キーワード:

エプチフィバチド エミデルチド リュープロレリン ロイプロレリン·酢酸 3-(2-ナフタレニル)-D-Ala-L-Cys(1)-L-Tyr-D-Trp-L-Lys-L-Val-L-Cys(1)-L-Thr-NH2 ゴナドレリン酢酸塩 リラグルチド ブセレリン LH-RH コートロシン デスロレリン アバレリックス メラノタンII BPC-157 メラノタンI ソマトスタチン-14 ヘキサレリン Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
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