AMINOPURVALANOL A
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- CAS番号.
- 220792-57-4
- 化学名:
- 别名:
- 英語名:
- AMINOPURVALANOL A
- 英語别名:
- NG-97;AMINOPURVALANOL A;AMINOPURVALANOL A (APURV);(R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol;(2R)-2-[[6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL;1-Butanol, 2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-;inhibit,actin polymerization,Inhibitor,Cyclins,cancer cell differention,G2/M-phase transition,Apoptosis,Aminopurvalanol A,Cyclin dependent kinase,CDK,sperm fertilizing ability
- CBNumber:
- CB4164371
- 化学式:
- C19H26ClN7O
- 分子量:
- 403.91
- MOL File:
- 220792-57-4.mol
- MSDS File:
- SDS
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AMINOPURVALANOL A 物理性質
- 沸点 :
- 639.0±65.0 °C(Predicted)
- 比重(密度) :
- 1.40±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Store at +4°C
- 溶解性:
- Soluble to 100 mM in DMSO
- 外見 :
- 白から茶色がかった固体。
- 酸解離定数(Pka):
- 14.51±0.10(Predicted)
- 色:
- Off-white to light yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
AMINOPURVALANOL A 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC2072 |
Aminopurvalanol A |
220792-57-4 |
10mg |
￥79000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC2072 |
Aminopurvalanol A |
220792-57-4 |
50mg |
￥283000 |
2024-03-01 |
購入 |
AMINOPURVALANOL A 化学特性,用途語,生産方法
生物活性
Cell-permeable cyclin-dependent kinase inhibitor. IC 50 values are 0.033, 0.033, 0.028 and 0.020 μ M for cdk1/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5/p35 respectively. Inhibits ERK1 (IC 50 = 12.0 μ M) and ERK2 (IC 50 = 3.1 μ M) and is 3000-fold selective over a range of other protein kinases (IC 50 > 100 μ M). Arrests cell cycle at G 2 /M boundary (IC 50 = 1.25 μ M), and induces apoptosis at concentrations > 10 μ M.
酵素阻害剤
This cell-permeable purvalanol derivative (FW = 403.92 g/mol), also named (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)- 9H-purin-2-yl]amino]-3-methyl-1-butanol, targets cdk1/cyclin B (IC50 = 0.033 μM), cdk2/cyclin A (IC50 = 0.033 μM), cdk2/cyclin E (IC50 = 0.028 μM), and cdk5/p35 (IC50 = 0.020 μM). It also inhibits ERK1 (IC50 = 12 μM) and ERK2 (IC50 = 3.1 μM), with 3000-times greater selectivity versus a range of other protein kinases (IC50 > 100 μM). Aminopurvalanol A arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations > 10 μM.
AMINOPURVALANOL A 上流と下流の製品情報
原材料
準備製品
AMINOPURVALANOL A 生産企業
Global( 43)Suppliers
220792-57-4()キーワード:
- 220792-57-4
- NG-97
- AMINOPURVALANOL A
- (2R)-2-[[6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL
- AMINOPURVALANOL A (APURV)
- 1-Butanol, 2-[[6-[(3-amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-
- (R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol
- inhibit,actin polymerization,Inhibitor,Cyclins,cancer cell differention,G2/M-phase transition,Apoptosis,Aminopurvalanol A,Cyclin dependent kinase,CDK,sperm fertilizing ability