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SU 16f

化学構造式
251356-45-3
CAS番号.
251356-45-3
化学名:
别名:
英語名:
SU 16f
英語别名:
SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
CBNumber:
CB42501833
化学式:
C24H22N2O3
分子量:
386.44
MOL File:
251356-45-3.mol

SU 16f 物理性質

沸点 :
661.7±55.0 °C(Predicted)
比重(密度) :
1.292±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at RT
溶解性:
Soluble to 100 mM in DMSO
外見 :
濃いオレンジ色の固体
酸解離定数(Pka):
4?+-.0.10(Predicted)
色:
Yellow to orange

安全性情報

SU 16f 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3304
SU 16f 		251356-45-3 10mg ￥82000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC3304
SU 16f 		251356-45-3 50mg ￥344000 2024-03-01 購入

SU 16f 化学特性,用途語,生産方法

使用

SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor.

一般的な説明

A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM).

SU 16f 上流と下流の製品情報

原材料

準備製品

SU 16f 生産企業

Global( 58)Suppliers
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  • 251356-45-3
  • 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
  • (Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
  • SU 16f
  • PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
  • 1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
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