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N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide

化学構造式
329196-48-7
CAS番号.
329196-48-7
化学名:
别名:
英語名:
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
英語别名:
SANT-2;Hh Signaling Antagonist XIV, SANT-2;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
CBNumber:
CB42518880
化学式:
C26H26ClN3O4
分子量:
479.96
MOL File:
329196-48-7.mol
MSDS File:
SDS

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide 物理性質

融点 :
210-211℃
比重(密度) :
1.287±0.06 g/cm3(Predicted)
貯蔵温度 :
-20°C
溶解性:
DMSO：可溶20mg/mL、透明
酸解離定数(Pka):
10.95±0.10(Predicted)
外見 :
白い粉
色:
白からベージュ

安全性情報

WGK Germany  3

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01BVI1976-1
SANT-2 		329196-48-7 1mg ￥16900 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01BVI1976-5
SANT-2 		329196-48-7 5mg ￥48100 2020-09-21 購入
Sigma-Aldrich Japan SML0644 ≥95% (HPLC)
SANT-2 ≥95% (HPLC)		 329196-48-7 5mg ￥21100 2024-03-01 購入
Sigma-Aldrich Japan SML0644 ≥95% (HPLC)
SANT-2 ≥95% (HPLC)		 329196-48-7 25mg ￥84000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TOC3617
SANT-2 		329196-48-7 10mg ￥50000 2021-03-23 購入

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide 化学特性,用途語,生産方法

使用

SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.

一般的な説明

A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).

Biochem/physiol Actions

SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide 上流と下流の製品情報

原材料

準備製品

N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide 生産企業

Global( 49)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15848 69
Shanghai Tauto Biotech Co., Ltd. 021-51320588
tauto@tautobiotech.com China 3989 66
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9707 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123
 1014988033@qq.com China 4997 55
BOC Sciences --
 info@bocsci.com USA 0 65

329196-48-7()キーワード:

17,23β-エポキシ-3β-ヒドロキシベラトラマン-11-オン N-[3-(4-ピリジニル)ベンジル]-N-[4β-(メチルアミノ)シクロヘキサン-1α-イル]-3-クロロベンゾ[b]チオフェン-2-カルボアミド ソニデギブ ソニデギブリン酸塩 パルモルファミン
  • 329196-48-7
  • N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
  • SANT-2
  • Hh Signaling Antagonist XIV, SANT-2
  • Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
  • Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem
  • N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide
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