N-{5-[2-(アセチルスルファニル)アセチル]ピリジン-2-イル}-4-[3-(ジメチルアミノ)プロポキシ]ベンゼンスルホンアミド 化学特性,用途語,生産方法
説明
KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC
50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively). It exhibits broad spectrum antitumor activity
in vitro and
in vivo. KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.
N-{5-[2-(アセチルスルファニル)アセチル]ピリジン-2-イル}-4-[3-(ジメチルアミノ)プロポキシ]ベンゼンスルホンアミド 上流と下流の製品情報
原材料
準備製品