3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo- 化学特性,用途語,生産方法
一般的な説明
A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in
C. elegans (EC
50 ~ 0.1 μM) and reduce the expression level of fat-7 (a
C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 μM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in
de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No.
171260).
3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo- 上流と下流の製品情報
原材料
準備製品