GLPG 0492 化学特性,用途語,生産方法
説明
GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC
50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-
mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization.
使用
GLPG-0492 is a non-steroidal Selective Androgen Receptor Modulator (SARM), which can be used to reduce muscle loss while sparing reproductive tissues.
GLPG 0492 上流と下流の製品情報
原材料
準備製品