PHPS1 ナトリウム塩 水和物
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- CAS番号.
- 314291-83-3
- 化学名:
- PHPS1 ナトリウム塩 水和物
- 别名:
- PHPS1 ナトリウム塩 水和物
- 英語名:
- PTP Inhibitor V, PHPS1
- 英語别名:
- PHPS1;PHPS1 sodium salt;PTP Inhibitor V, PHPS1;PHPS1 sodium salt hydrate;PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem;4-(2-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid;Benzenesulfonic acid, 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-;atherosclerosis,kidney,Erk1/2,inhibit,PTP1B,prostate,Shp1,PHPS1,colon,Phosphatase,lung,Shp2,carcinoma,cancer,Inhibitor;4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate
- CBNumber:
- CB42685465
- 化学式:
- C21H15N5O6S
- 分子量:
- 465.44
- MOL File:
- 314291-83-3.mol
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PHPS1 ナトリウム塩 水和物 物理性質
- 比重(密度) :
- 1.54±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：可溶10mg/mL、透明（加温）
- 酸解離定数(Pka):
- -2.90±0.40(Predicted)
- 外見 :
- 個体
- 色:
- 赤
- InChI:
- InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,22H,(H,30,31,32)
- InChIKey:
- VIQSBJOMLQLAKC-UHFFFAOYSA-N
- SMILES:
- C1(S(O)(=O)=O)=CC=C(NN=C2C(=O)N(C3=CC=CC=C3)N=C2C2=CC=C([N+]([O-])=O)C=C2)C=C1
PHPS1 ナトリウム塩 水和物 価格
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PHPS1 ナトリウム塩 水和物 化学特性,用途語,生産方法
説明
PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of SH-PTP2 (Shp-2) (IC50 and Ki = 2.1 and 0.73μM, respectively). PHPS1 inhibits PCPTP1 (ECPTP), PTP1B, SH-PTP1 (Shp1), mycobacterium MptpA only at higher concentrations (IC50 ;= 5.4, 19, 30, and 39 μM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 μM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation
使用
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) sodium salt hydrate has been used as a protein-tyrosine phosphatase (shp2) inhibitor to study its effects on bisphenol A (BPA) and nonyl phenol (NP)-induced cell proliferation of MCF7 cell. It has also been used as a shp2 inhibitor to study its pro-atherosclerotic or atheroprotective effect
in vivo and
in vitro.
Biochem/physiol Actions
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) represses E2-induced gene transcription and rapid DNA synthesis. It also blocks mitogen-activated protein kinase (ERK1/2) activation and reduces the cigarette smoke induced-inflammatory response in mouse lungs.
PHPS1 ナトリウム塩 水和物 上流と下流の製品情報
原材料
準備製品
PHPS1 ナトリウム塩 水和物 生産企業
Global( 54)Suppliers
- 314291-83-3
- PHPS1 sodium salt hydrate
- PTP Inhibitor V, PHPS1
- PHPS1 sodium salt
- PHPS1
- 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate
- PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem
- Benzenesulfonic acid, 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-
- 4-(2-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid
- atherosclerosis,kidney,Erk1/2,inhibit,PTP1B,prostate,Shp1,PHPS1,colon,Phosphatase,lung,Shp2,carcinoma,cancer,Inhibitor
- PHPS1 ナトリウム塩 水和物