4-Hydroxyalternariol

 化学構造式
959417-21-1
CAS番号.
959417-21-1
化学名:
别名:
英語名:
4-Hydroxyalternariol
英語别名:
4-Hydroxyalternariol;Hydroxyalternariol, 4-;Alternariol Impurity 18;3,4,7,9-tetrahydroxy-1-methylbenzo[c]chromen-6-one;3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,4,7,9-tetrahydroxy-1-methyl-
CBNumber:
CB42720810
化学式:
C14H10O6
分子量:
274.23
MOL File:
959417-21-1.mol

4-Hydroxyalternariol 物理性質

貯蔵温度 :
Store at -20°C
溶解性:
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
外見 :
A solid

安全性情報

4-Hydroxyalternariol 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

4-Hydroxyalternariol 化学特性,用途語,生産方法

説明

4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 μM under cell-free conditions.

使用

4-Hydroxyalternariol is the fully demethylated tetraphenol analogue of the benzopyranone graphislactones. Hydroxyalternariol was isolated as a major co-metabolite of a graphislactone A-producing fungus. Hydroxyalternariol has not previously been available for study and no bioactivity has been reported to date.

4-Hydroxyalternariol 上流と下流の製品情報

原材料

準備製品


4-Hydroxyalternariol 生産企業

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  • 959417-21-1
  • 4-Hydroxyalternariol
  • Hydroxyalternariol, 4-
  • 3,4,7,9-tetrahydroxy-1-methylbenzo[c]chromen-6-one
  • 6H-Dibenzo[b,d]pyran-6-one, 3,4,7,9-tetrahydroxy-1-methyl-
  • Alternariol Impurity 18
  • 3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one
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