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PFK-158

化学構造式
1462249-75-7
CAS番号.
1462249-75-7
化学名:
别名:
英語名:
PFK-158
英語别名:
PFK-158;PFK-158;PFK 158;PFK-158 free base;PFK-158, ACT-PFK-158;(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
CBNumber:
CB43034954
化学式:
C18H11F3N2O
分子量:
328.29
MOL File:
1462249-75-7.mol
MSDS File:
SDS

PFK-158 物理性質

沸点 :
466.3±45.0 °C(Predicted)
比重(密度) :
1.346±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
外見 :
A crystalline solid
酸解離定数(Pka):
2.46±0.10(Predicted)
色:
White to light yellow

安全性情報

PFK-158 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan SML3145 ≥98% (HPLC)
PFK-158 ≥98% (HPLC)		 1462249-75-7 5MG ￥14200 2024-03-01 購入
Sigma-Aldrich Japan SML3145 ≥98% (HPLC)
PFK-158 ≥98% (HPLC)		 1462249-75-7 25MG ￥45500 2024-03-01 購入

PFK-158 化学特性,用途語,生産方法

説明

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.

PFK-158 上流と下流の製品情報

原材料

準備製品

PFK-158 生産企業

Global( 63)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32760 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10318 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10522 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028
 kathy@hbyinsheng.com China 3582 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2923 55

1462249-75-7()キーワード:

銀
  • 1462249-75-7
  • PFK-158
  • PFK-158, ACT-PFK-158
  • (2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one
  • PFK-158;PFK 158
  • PFK-158 free base
  • 2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-
  • (E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one
  • p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
  • (E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one
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