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SR9238

化学構造式
1416153-62-2
CAS番号.
1416153-62-2
化学名:
别名:
英語名:
SR9238
英語别名:
SR9238;SR9238 >=98% (HPLC);SR9238;SR-9238;SR 9238;Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor;Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate;Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate;Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate;2-Furancarboxylic acid, 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-, ethyl ester
CBNumber:
CB43152748
化学式:
C31H33NO7S2
分子量:
595.73
MOL File:
1416153-62-2.mol

SR9238 物理性質

沸点 :
787.7±70.0 °C(Predicted)
比重(密度) :
1.268±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMF: 5 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 5 mg/ml
酸解離定数(Pka):
-10.53±0.70(Predicted)
外見 :
粉
色:
白からベージュ

安全性情報

SR9238 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan SML1510 ≥98% (HPLC)
SR9238 ≥98% (HPLC)		 1416153-62-2 5mg ￥21800 2024-03-01 購入
Sigma-Aldrich Japan SML1510 ≥98% (HPLC)
SR9238 ≥98% (HPLC)		 1416153-62-2 25mg ￥69900 2024-03-01 購入

SR9238 化学特性,用途語,生産方法

使用

SR 9238 is an LXR inverse agonist, which also suppresses fibrosis in a model of non-alcoholic steatohepatitis.

Biochem/physiol Actions

SR9238 is liver selective LXR inverse agonist with high potency for both LXRα and LXRβ with an IC50 of 214 nM for LXRα and 43 nM for LXRβ. Metabolic syndrome is often accompanied by liver problems, such as fatty liver (nonalcoholic hepatosteatosis), associated with increased lipogenesis. Liver X receptors α and β (LXRα and LXRβ) are known to induce lipogenesis by increasing transcription of lipogenic enzyme genes, so it was hoped LXR antagonists might be of use in fatty liver. In a mouse model of nonalcoholic hepatosteatosis, SR9238 reduced the expression of lipogenic genes, and suppressed hepatic lipogenesis, inflammation and hepatic lipid accumulation. It was also effective in reduction of hepatic fibrosis in another study. Additionally in diet induced obese mice, SR9238 suppressed plasma cholesterol levels.

SR9238 上流と下流の製品情報

原材料

準備製品

SR9238 生産企業

Global( 49)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Chemia Biotechnology（Shanghai） Co., Ltd 		+8613816753574
 info@chemia-pharm.com CHINA 311 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070
info@chemlin.com.cn China 18080 64
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
 3003855609@qq.com China 7887 56
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51471 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4264 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9707 58

1416153-62-2()キーワード:

2-アミノ-3-(4-クロロベンゾイル)-4,5,6,7-テトラヒドロベンゾ[b]チオフェン
  • 1416153-62-2
  • SR9238
  • Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate
  • SR9238;SR-9238;SR 9238
  • 2-Furancarboxylic acid, 5-[[[[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-, ethyl ester
  • SR9238 >=98% (HPLC)
  • Liver X receptor,SR-9238,SR 9238,LXR,SR9238,inhibit,Inhibitor
  • Ethyl 5-(((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenyl)sulfonamido)methyl)furan-2-carboxylate
  • Ethyl 5-((2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)phenylsulfonamido)methyl)furan-2-carboxylate
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