抗MUC1抗体(AB1) ウサギ宿主抗体 化学特性,用途語,生産方法
使用
Anti-ETFA (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1μg/mL.
一般的な説明
MUC1 (Mucin 1) is O-glycosylated, carbohydrate rich, transmembrane glycoprotein. It has approximately 13 members in the family. It is localized on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It is overexpressed in several epithelial cancers, including pancreatic ductal adenocarcinoma. It is a heterodimer consisting of N-terminal (MUC1-N) and C-terminal (MUC1-C) subunits. N-terminal (MUC1-N) end contains tandem repeats (VNTR) which forms the mucin component.
Biochem/physiol Actions
ETFA (electron-transfer-flavoprotein, α polypeptide) encodes a flavoprotein that belongs to ETF α-subunit/FixB family. It facilitates the catalysis of initial step of the mitochondrial fatty acid β-oxidation. Increase in the cellular levels of ETFA leads to activation of JNK1/2 and NFκB signaling modules which in turn facilitates the t-BHP induced apoptosis cascade and cell viability.
抗MUC1抗体(AB1) ウサギ宿主抗体 上流と下流の製品情報
原材料
準備製品