アラメチシン FROM TRICHODERMA VIRIDE
|
|
|
- CAS番号.
- 27061-78-5
- 化学名:
- アラメチシン FROM TRICHODERMA VIRIDE
- 别名:
- アラメチシン FROM TRICHODERMA VIRIDE;アラメチシン, レディーメイド溶液 FROM TRICHODERMA VIRIDE
- 英語名:
- ALAMETHICINRESEARCH GRADE
- 英語别名:
- Alamethicin (U-22324);ALAMETHICINRESEARCH GRADE;Alamethicin, Ready Made Solution;alamethicin from trichoderma viride;Alamethicin, Ready Made Solution from Trichoderma viride;Peptaibol coMplex. Additional synonyMs for the Major coMponent, alaMethicin I: AlaMethicin F30, AlaMethicin-gaMMa, U 22324;Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol;Almethicin, Antibiotic U-22324, 6-(2-methylalanine)-8-L-leucine-9-de-L-valine-12-(2-methylalanine)-13a-endo-(2-methylalanine)-18-L-glutamine-19-(N(1)-(1-(hydroxymethyl)-3-methylbutyl)-L-glutamamide)-];N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1;(3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-AcetaMido-2-Methylpropanoyl)pyrrolidin-2-yl)-15-(3-aMino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,2,18,18,24,24,33,33-dodecaMethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,1
- CBNumber:
- CB4500700
- 化学式:
- C92H150N22O25
- 分子量:
- 1964.3078
- MOL File:
- 27061-78-5.mol
|
アラメチシン FROM TRICHODERMA VIRIDE 物理性質
- 闪点 :
- 87℃
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO (最大 25mg/ml) またはメタノール (最大 10mg/ml) に可溶。
- 外見 :
- DMSO溶液
- 色:
- オフホワイト
- BRN :
- 5213858
- 安定性：:
- 安定。
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 主な危険性 |
T |
|
|
| Rフレーズ |
25 |
|
|
| Sフレーズ |
45 |
|
|
| RIDADR |
UN 3462 6.1/PG 3 |
|
|
| WGK Germany |
3 |
|
|
| F |
10-21 |
|
|
| HSコード |
29419090 |
|
|
| 絵表示（GHS） |
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
| 注意書き |
|
アラメチシン FROM TRICHODERMA VIRIDE 価格
もっと(11)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY11425 |
Alamethicin |
27061-78-5 |
1mg |
￥12300 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CAY11425 |
Alamethicin |
27061-78-5 |
5mg |
￥32800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A4665 |
アラメチシン from Trichoderma viride ≥98% (HPLC)
Alamethicin from Trichoderma viride ≥98% (HPLC) |
27061-78-5 |
5mg |
￥72700 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A5361 |
アラメチシン, レディーメイド溶液 from Trichoderma viride 5?mg/mL in DMSO, sterile; 0.2 μm filtered
Alamethicin, Ready Made Solution from Trichoderma viride 5?mg/mL in DMSO, sterile; 0.2 μm filtered |
27061-78-5 |
500μl |
￥58400 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A4665 |
アラメチシン from Trichoderma viride ≥98% (HPLC)
Alamethicin from Trichoderma viride ≥98% (HPLC) |
27061-78-5 |
10mg |
￥123000 |
2024-03-01 |
購入 |
アラメチシン FROM TRICHODERMA VIRIDE 化学特性,用途語,生産方法
説明
Alamethicin is an antibiotic peptide belonging to a class of membrane active peptides of fungal origin called peptaibols. It contains an unusual amphiphilic amino acid, 2-
aminoisobutyric acid, which strongly induces helical peptide structures and forms voltage-
gated ion channels in the lipid bilayers of cell membranes. Alamethicin is often used to study ion channel assembly, voltage gating, and peptide-
membrane interactions. Alamethicin is also widely used as agent to induce various physiological and defense responses in eukaryotic cells including plants.
化学的特性
solid
使用
Alamethicin is an acidic linear peptaibol complex with potent antibiotic activity, containing 20 “amino acids”, with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F30 acts an ionopohore, transporting ions through membranes and artificial lipid membranes and forming voltage-dependent ion channels in lipid bilayer membranes. Alamethicin is co-produced with a parallel, neutral, linear peptaibol complex (alamethicin F50). The relative composition of alamethicin is a variable mixture of the acidic and neutral complexes, but reports on alamethacin do not generally specify the ratio of F50 to F30, and comparative data between the complexes is scant.
一般的な説明
Alamethicin belongs to the peptaibol family of antimicrobial peptides. It is mainly composed of hydrophobic amino acids. It possess a helical structure with a movable hinge region at Gly-11 position.
純化方法
Recrystallise alamethicin from MeOH. [Panday et al. J Am Chem Soc 99 8469 1977.] The acetate has m 195-180o from MeOH/Et2O, and the acetate-methyl ester [64936-53-4] has m 145-140o from aqueous MeOH.
アラメチシン FROM TRICHODERMA VIRIDE 上流と下流の製品情報
原材料
準備製品
アラメチシン FROM TRICHODERMA VIRIDE 生産企業
Global( 84)Suppliers
アラメチシン FROM TRICHODERMA VIRIDE スペクトルデータ(IR)
27061-78-5(アラメチシン FROM TRICHODERMA VIRIDE)キーワード:
- 27061-78-5
- Peptaibol coMplex. Additional synonyMs for the Major coMponent, alaMethicin I: AlaMethicin F30, AlaMethicin-gaMMa, U 22324
- Alamethicin, Ready Made Solution from Trichoderma viride
- Alamethicin (U-22324)
- ALAMETHICINRESEARCH GRADE
- alamethicin from trichoderma viride
- Almethicin, Antibiotic U-22324, 6-(2-methylalanine)-8-L-leucine-9-de-L-valine-12-(2-methylalanine)-13a-endo-(2-methylalanine)-18-L-glutamine-19-(N(1)-(1-(hydroxymethyl)-3-methylbutyl)-L-glutamamide)-]
- Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol
- (3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-AcetaMido-2-Methylpropanoyl)pyrrolidin-2-yl)-15-(3-aMino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,2,18,18,24,24,33,33-dodecaMethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,1
- N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1
- Alamethicin, Ready Made Solution
- アラメチシン FROM TRICHODERMA VIRIDE
- アラメチシン, レディーメイド溶液 FROM TRICHODERMA VIRIDE