GSK620

2088410-46-0

CAS番号.: 2088410-46-0

化学名:

别名:

英語名:: GSK620

英語别名:: GSK620;1-benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide;3,5-Pyridinedicarboxamide, N5-cyclopropyl-1,2-dihydro-N3-methyl-2-oxo-1-(phenylmethyl)-;Inhibitor,oral,GSK 620,phenotype,selectivity,GSK-620,whole,anti-inflammatory,GSK620,Epigenetic Reader Domain,inhibit,human,blood

CBNumber:: CB48067227

化学式:: C18H19N3O3

分子量:: 325.36

MOL File:: 2088410-46-0.mol

物理性質

安全性情報

用途語

生産企業 41

GSK620 物理性質

沸点 :: 618.6±55.0 °C(Predicted)

比重(密度) :: 1.30±0.1 g/cm3(Predicted)

貯蔵温度 :: Store at -20°C

溶解性:: DMSO : 62.5 mg/mL (192.09 mM; Need ultrasonic)

酸解離定数(Pka):: 12.43±0.20(Predicted)

外見 :: Solid

色:: White to off-white

InChI:: InChI=1S/C18H19N3O3/c1-19-17(23)15-9-13(16(22)20-14-7-8-14)11-21(18(15)24)10-12-5-3-2-4-6-12/h2-6,9,11,14H,7-8,10H2,1H3,(H,19,23)(H,20,22)

InChIKey:: QZZCUOVXHPAQRQ-UHFFFAOYSA-N

SMILES:: C1(=O)N(CC2=CC=CC=C2)C=C(C(NC2CC2)=O)C=C1C(NC)=O

安全性情報

GSK620 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

GSK620 化学特性,用途語,生産方法

in vitro

GSK620 shows an anti-inflammatory phenotype in human whole blood. Human blood samples are stimulated with LPS, which produces a strong immune response. The monocyte chemattractant protein 1 (MCP-1/CCL2) is measured. This is a chemokine which recruits monocytes, memory T cells, and dendritic cells to sites of inflammation. GSK620 reduces the MCP-1 response in a concentration-dependent manner with (an expected) ～1 log drop off in potency relative to the biochemical BRD4 BD2 potencies observed.

GSK620 上流と下流の製品情報

原材料

準備製品

GSK620 生産企業

Global( 41)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Wuhan Nutra Biotechnology Co.,Ltd	+8617786394783	nutrabiotech@outlook.com	China	300	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

2088410-46-0()キーワード:

4-[2-(4-アミノ-1,2,5-オキサジアゾール-3-イル)-1-エチル-7-[[(3S)-3-ピペリジニル]メトキシ]-1H-イミダゾ[4,5-c]ピリジン-4-イル]-2-メチル-3-ブチン-2-オール GSK650394 N-(ベンゾチアゾール-5-イル)-6-(イソプロピルスルホニル)キノリン-4-アミン

2088410-46-0
GSK620
1-benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide
Inhibitor,oral,GSK 620,phenotype,selectivity,GSK-620,whole,anti-inflammatory,GSK620,Epigenetic Reader Domain,inhibit,human,blood
3,5-Pyridinedicarboxamide, N5-cyclopropyl-1,2-dihydro-N3-methyl-2-oxo-1-(phenylmethyl)-