ジベンジルアミン 化学特性,用途語,生産方法
外観
無色～黄褐色, 澄明の液体
溶解性
エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。エタノール、エーテルに可溶。水に不溶。
用途
ゴム薬品、医薬品原料
化学的特性
colorless to light yellow oily liquid with ammonia odor. soluble in ethanol and ether, insoluble in water.
使用
Dibenzylamine is used to prepare rubber accelerator for the vulcanization process and reaction-stoppers. Dibenzylamine type accelerators reduce nitrosamine production in the compounding process. It is also used to produce dibenzyl-nitroso-amine.
製造方法
Dibenzylamine is obtained by the reaction of benzyl chloride and liquid ammonia in ethanol.
主な応用
Dibenzylamine is an important organic synthesis intermediate, mainly used to produce efficient and non-toxic vulcanization accelerators tetrabenzylthiuramdisulfide (TBZTD) and zinc dibenzyldithiocarbamate (ZBEC). Synthesize penicillin and curing agent for rubber and plastic curing, and can be used in the detection of cobalt, cyanate, and iron.
危険性
Dibenzylamine is danger.
H302 (99.32%): Harmful if swallowed [Warning Acute toxicity, oral]
H314 (57.43%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
H315 (42.57%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (42.57%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H412 (32.43%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
合成
The synthesis process of dibenzylamine comprises the following steps: reacting raw materials (benzaldehyde and ammonium hydroxide) for 20-70min at 60-120 DEG C under a hydrogen pressure of 0.5-2.0MPa in the presence of a catalyst, wherein alcohol with 1-4 carbon atoms can be added optionally to serve as an organic solvent and a phase transfer catalyst can be added optionally; by the end of the reaction, cooling, filtering to recover the catalyst, layering the filtrate to obtain a dibenzylamine product; and recycling and reusing excessive ammonium hydroxide.
純化方法
Purify the amine by distillation in a vacuum. It causes burns to the skin. The dihydrochloride has m 265-266o (from MeOH/HCl), and the tetraphenyl boronate has m 129-133o. [Bradley & Maisey J Chem Soc 247 1954, Hall J Phys Chem 60 63 1956, Donetti & Bellora J Org Chem 37 3352 1972, Beilstein 12 IV 2179.]
ジベンジルアミン 上流と下流の製品情報
原材料
準備製品
N-ベンジルヒドロキシルアミン塩酸塩
1,2,3,4,5,6,7,8-オクタチアシクロオクタン
トリベンジルアミン
3-アミノメチル-3-[ビス(フェニルメチル)アミノ]オキセタン
N,N-ジエチルベンジルアミン
ジベンジルジチオカルバミン酸ナトリウム水和物
5-[[ビス(フェニルメチル)アミノ]アセチル]-2-ヒドロキシベンズアミド
N,N,N',N'-テトラベンジルチウラムジスルフィド
1,2-ジアミノ-1,2-ジフェニルエタン