4-メトキシけい皮酸エチル
4-メトキシけい皮酸エチル 物理性質
- 融点 :
- 49°C
- 沸点 :
- 187 °C / 15mmHg
- 比重(密度) :
- 1.080±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 溶解性:
- クロロホルム(微量)、メタノール(微量)
- 外見 :
- Solid
- 色:
- オフホワイト
- 水溶解度 :
- insoluble in water
- BRN :
- 2210033
- LogP:
- 2.650 (est)
- NISTの化学物質情報:
- Ethyl p-methoxycinnamate(24393-56-4)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
|
注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
![](/GHS07.jpg) |
P264, P270, P301+P312, P330, P501 |
|
注意書き |
P264 |
取扱い後は皮膚をよく洗うこと。 |
P264 |
取扱い後は手や顔をよく洗うこと。 |
P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
P301+P312 |
飲み込んだ場合:気分が悪い時は医師に連絡する こと。 |
P501 |
内容物/容器を...に廃棄すること。 |
|
4-メトキシけい皮酸エチル 価格
もっと(13)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-2723 |
4-メトキシけい皮酸エチルエステル
4-Methoxycinnamic acid ethyl ester |
24393-56-4 |
1g |
¥10000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-2723 |
4-メトキシけい皮酸エチルエステル
4-Methoxycinnamic acid ethyl ester |
24393-56-4 |
25g |
¥35000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-2723 |
4-Methoxycinnamic acid ethyl ester |
24393-56-4 |
100g |
¥120000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-2723 |
4-Methoxycinnamic acid ethyl ester |
24393-56-4 |
10g |
¥36000 |
2023-06-01 |
購入 |
東京化成工業
|
M1204 |
4-メトキシけい皮酸エチル >98.0%(GC)
Ethyl 4-Methoxycinnamate
>98.0%(GC) |
24393-56-4 |
5g |
¥12900 |
2024-03-01 |
購入 |
4-メトキシけい皮酸エチル 化学特性,用途語,生産方法
外観
白色~ほとんど白色粉末~結晶
化学的特性
White crystalline, soluble in methanol, ethanol, DMSO and other organic solvents, derived from cinnamon.
使用
Ethyl 4-methoxycinnamate is an derivative of 4-methoxycinnamic acid, an antihyperglycemic/hypoglycemic agent that works by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.
製造方法
Ethyl 4-methoxycinnamate synthesis: 4-Methoxycinnamic Acid (0.60 g, 3.36 mmol) was dissolved in 10 mL of dry N,N-dimethylformamide (DMF) in a 25-mL, roundbottomed flask. Cesium carbonate (1.65 g, 5.06 mmol) was added followed by iodoethane (1.0 mL, 12.5 mmol). The flask was capped (rubber septum) and the heterogeneous mixture stirred vigorously at 50 °C for one hour. After this time, HCl (1.0 M, 4.0 mL) was added to quench the reaction. The liquid was decanted from any remaining solid and extracted with 3 : 1 hexanes/ethyl acetate (2 x 10 mL). The organic layer was washed with brine (20 mL), dried with MgSO4, filtered, and solvent removed. The remaining oil solidified on standing to form colorless prisms.
![説明図](/NewsImg/2022-08-25/6379706254798423238664591.jpg)
Synthesis of ethyl 4-methoxycinnamate
一般的な説明
Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo. EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats. It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (<10 μg/ml) also reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.
4-メトキシけい皮酸エチル 上流と下流の製品情報
原材料
準備製品
4-メトキシけい皮酸エチル 生産企業
Global( 244)Suppliers
24393-56-4(4-メトキシけい皮酸エチル)キーワード:
- 24393-56-4
- 3-(4-METHOXYPHENYL)ACRYLIC ACID ETHYL ESTER
- ETHYL 4-METHOXYCINNAMATE
- RARECHEM AL BI 0241
- Methoxycinnamicacidethylester
- 4-METHOXYCINNAMIC ACID ETHYL ESTER 98+%
- P-methoxyl ethyl cinnamate
- 4-Methoxycinnamic Acid Ethyl Ester
Ethyl 3-(4-Methoxyphenyl)acrylate
3-(4-Methoxyphenyl)acrylic Acid Ethyl Ester
- ParaMethoxyethylcinnaMate
- 1-(tert-butoxycarbonyl)-4-(4-Methoxyphenyl)pyrrolidine-3-carboxylic acid
- (E)-Ethyl 3-(4-Methoxyphenyl)acrylate
- Ethyl 4-Methoxyciamate
- (E)-3-(4-Methoxyphenyl)-2-propenoic acid ethyl ester
- Ethyl (E)-3-(4-methoxyphenyl)-2-propenoate
- trans-4-Methoxycinnamic acid ethyl ester
- Ethyl 4-methoxycinmate
- Ethyl para-methoxycinnamate
- 2-Propenoic acid, 3-(4-methoxyphenyl)-, ethyl ester, (2E)-
- Ethyl 4-methoxycinnamate USP/EP/BP
- Ferulic acid,ethyl ester,4-Methoxycinnamic Acid Ethyl Ester,Ethyl trans-4-methoxycinnamate,ethyl p-methoxycinnamate,3-(4-Methoxyphenyl)acrylic Acid
- Ethyl trans-p-methoxycinnamate
- trans-p-Methoxycinnamic acid ethyl ester
- Ethyl4-Methoxycinnamate>
- EPMC
- 4-METHOXYCINNAMIC ACID ETHYL ESTER
- ETHYL P-METHOXYCINNAMATE
- ETHYL 3-(4-METHOXYPHENYL)ACRYLATE
- Ethyl trans-4-methoxycinnamate
- ethyl (E)-4-methoxycinnamate
- (E)-Ethyl p-methoxycinnamate
- Ethyl trans-4-methoxycinnamate-d3
- 4-メトキシけい皮酸エチル
- TRANS‐4‐メトキシけい皮酸エチル
- 4-メトキシけい皮酸エチルエステル
- 4‐メトキシ‐けい皮酸エチル
- trans-4-メトキシけい皮酸エチル