抗FKHRL1(FOXO3A)抗体 ウサギ宿主抗体 化学特性,用途語,生産方法
使用
Anti-FKHRL1 (FOXO3a) antibody produced in rabbit has been used in:
- immunohistochemistry
- western blotting
- immunofluorescence staining
一般的な説明
Forkhead family transcription factor (FKHRL1), also known as FOX3a, is a member of the forkhead transcription factor superfamily. In FKHRL1 (FOX3a), there are three PKB phosphorylation consensus sites, Thr
32, Ser
253, and Ser
315. Thr
32 and Ser
253 are phosphorylated by PKB after induction by survival factors such as IGF-1.
Biochem/physiol Actions
Forkhead transcription factor superfamily proteins act as the targets of the phosphoinositide-3-kinase–protein kinase B/Akt (PI3K-PKB) pathway. FKHRL1/FOXO3a modulates the expression of several genes that regulate DNA repair in response to stress at the G2-M checkpoint and aging. Other genes that are regulated by FKHRL1 include mitotic genes such as cyclin B and polo-like kinase (plk). Antibodies reacting specifically with FKHRL1 (FOXO3) may be useful in studying the expression and function of the protein, as well as for correlating their expression pattern with physiological functions or pathological conditions.
抗FKHRL1(FOXO3A)抗体 ウサギ宿主抗体 上流と下流の製品情報
原材料
準備製品