JTE-013
|
|
- CAS番号.
- 383150-41-2
- 化学名:
- JTE-013
- 别名:
- N-(2,6-ジクロロ-4-ピリジル)-2-[1,3-ジメチル-4-(1-メチルエチル)-1H-ピラゾロ[3,4-b]ピリジン-6-イル]ヒドラジンカルボアミド;JTE-013;1-(2,6-ジクロロピリジン-4-イル)-3-{[1,3-ジメチル-4-(プロパン-2-イル)-1H-ピラゾロ[3,4-b]ピリジン-6-イル]アミノ}尿素
- 英語名:
- JTE-013
- 英語别名:
- CS-2553;JTE-013 HCl;JTE-013;JTE 013;JTE013;LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013;1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide;N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide;N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide
- CBNumber:
- CB52591408
- 化学式:
- C17H19Cl2N7O
- 分子量:
- 408.29
- MOL File:
- 383150-41-2.mol
- MSDS File:
- SDS
|
JTE-013 物理性質
- 比重(密度) :
- 1.50±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO:20mg/mL以上
- 酸解離定数(Pka):
- 9.32±0.43(Predicted)
- 外見 :
- 粉
- 色:
- ホワイトからオフホワイト
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
主な危険性 |
T |
|
|
Rフレーズ |
25 |
|
|
Sフレーズ |
45 |
|
|
RIDADR |
UN 2811 6.1 / PGIII |
|
|
WGK Germany |
3 |
|
|
絵表示(GHS) |
|
注意喚起語 |
危険 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
注意書き |
P301+P310 |
飲み込んだ場合:直ちに医師に連絡すること。 |
|
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
Sigma-Aldrich Japan
|
J4080 |
≥98% (HPLC)
JTE-013 ≥98% (HPLC) |
383150-41-2 |
5mg |
¥29800 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
J4080 |
≥98% (HPLC)
JTE-013 ≥98% (HPLC) |
383150-41-2 |
25mg |
¥113000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC2392 |
JTE 013 |
383150-41-2 |
10mg |
¥82000 |
2023-06-01 |
購入 |
JTE-013 化学特性,用途語,生産方法
説明
Sphingosine-
1-
phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-
coupled receptors, S1P
1/EDG-
1, S1P
2/EDG-
5, S1P
3/EDG-
3, S1P
4/EDG-
6, and S1P
5/EDG-
8. JTE-
013 is a potent, selective sphingosine-
1-
phosphate 2 (S1P
2) receptor antagonist that binds to the human and rat receptors with IC
50 values of 17 and 22 nM, respectively, (IC
50 values >10 μM for human S1P
1 and S1P
3). It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-
013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells. JTE-
013 inhibits S1P-
induced contraction of, as well as cyclic AMP accumulation in, coronary artery smooth muscle cells.
使用
JTE-013 has been used in
in vitro blood?brain barrier (BBB) and blood?tumor barrier (BTB) assays.
Biochem/physiol Actions
JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.
JTE-013 上流と下流の製品情報
原材料
準備製品
JTE-013 生産企業
Global( 70)Suppliers
- 383150-41-2
- 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide
- 1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea
- 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide
- CS-2553
- N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide
- JTE-013;JTE 013;JTE013
- 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea
- Hydrazinecarboxamide, N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-
- N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide
- JTE-013 HCl
- LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013
- N-(2,6-ジクロロ-4-ピリジル)-2-[1,3-ジメチル-4-(1-メチルエチル)-1H-ピラゾロ[3,4-b]ピリジン-6-イル]ヒドラジンカルボアミド
- JTE-013
- 1-(2,6-ジクロロピリジン-4-イル)-3-{[1,3-ジメチル-4-(プロパン-2-イル)-1H-ピラゾロ[3,4-b]ピリジン-6-イル]アミノ}尿素