アナグリプチン
アナグリプチン 物理性質
- 融点 :
- 115 - 119°C
- 比重(密度) :
- 1.33±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Refrigerator
- 溶解性:
- クロロホルム（微量）、ジクロロメタン（微量）、DMSO（微量）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 12.40±0.46(Predicted)
- 色:
- ホワイトからオフホワイト
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
|
| 注意書き |
| P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
アナグリプチン 価格
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
アナグリプチン 化学特性,用途語,生産方法
効能
糖尿病治療薬, DPP-4阻害薬
商品名
スイニー (三和化学研究所); スイニー (三和化学研究所)
説明
Anagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that was approved
in Japan in November 2012 for the treatment of patients with Type 2 diabetes
mellitus (T2DM).
Anagliptin (also known asSK-0403) is a treatment for diabetes based on inhibition of DPP-4, an enzyme that is responsible for degradation of glucagon-like peptide 1 (GLP-1), a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates
insulin secretion and inhibits glucagon secretion, which leads to lower
levels of plasma glucose. Following the introduction of the first DPP-4 inhibitor, sitagliptin, in 2006, several members of the gliptin class have been approved worldwide. Anagliptin was discovered from an effort to replace
a metabolically labile isoindoline group from an earlier DPP-4 inhibitor series with a stable bioisostere. Anagliptin is a potent DPP-4 inhibitor, with an IC
50=3.8 nM and >10,000-fold selectivity over inhibition of DPP-8 and DPP-9.
臨床応用
Anagliptin, which is marketed as Beskoa or Suiny, is a dipeptidyl peptidase–IV (DPP-4) inhibitor
which was approved in September 2012 and launched in November 2012 in Japan for the treatment of
Type II diabetes. The drug was co-developed by three Japanese companies; Kowa, Sanwa Kagaku and
JW pharmaceutical. Anagliptin, which is more selective against several recombinant human proteases by comparison to sitagliptin and vildagliptin, has more than 10,000-fold selectivity over the
structurally homologous DPP-8 and DPP-9 enzymes.
アナグリプチン 上流と下流の製品情報
原材料
準備製品
アナグリプチン 生産企業
Global( 119)Suppliers
739366-20-2(アナグリプチン)キーワード:
- 739366-20-2
- Anagliptin
- N-[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]aMino]-2-Methylpropyl]-2-Methyl-6-pyrazolo[1,5-a]pyriMidinecarboxaMide
- Anagliptin API
- Suiny
- (S)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylaMino)-2-Methylpropyl)-2-Methylpyrazolo[1,5-a]pyriMidine-6-carboxaMide
- N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
- (R)-N-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylamino)-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
- N-[2-[[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
- SK-0403
- SUINY;SK-0403
- Pyrazolo[1,5-a]pyrimidine-6-carboxamide, N-[2-[[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethyl]amino]-2-methylpropyl]-2-methyl-
- Anagliptin (SK-0403)
- Anagliptin-d7Q: What is
Anagliptin-d7 Q: What is the CAS Number of
Anagliptin-d7 Q: What is the storage condition of
Anagliptin-d7 Q: What are the applications of
Anagliptin-d7
- AnagliptinQ: What is
Anagliptin Q: What is the CAS Number of
Anagliptin Q: What is the storage condition of
Anagliptin Q: What are the applications of
Anagliptin
- アナグリプチン
- アナグリプチン (JAN)
- スイニー
- ベスコア
- N-[2-({2-[(2S)-2-シアノピロリジン-1-イル]-2-オキソエチル}アミノ)-2-メチルプロピル]-2-メチルピラゾロ[1,5-a]ピリミジン-6-カルボキサミド
- N-[2-[2-((S)-2-シアノピロリジン-1-イル)-2-オキソエチルアミノ]-2-メチルプロピル]-2-メチルピラゾロ[1,5-a]ピリミジン-6-カルボキサミド
- N-[2-[2-[(2S)-2-シアノピロリジノ]-2-オキソエチルアミノ]-2-メチルプロピル]-2-メチルピラゾロ[1,5-a]ピリミジン-6-カルボアミド