ダファクロン酸A

949004-12-0

CAS番号.: 949004-12-0

化学名:: ダファクロン酸A

别名:: Δ7-ダファクロン酸;(2S,6R)-6-[(1R,3aR,5aS,9aS,9bR,11aR)-9a,11a-ジメチル-7-オキソ-1H,2H,3H,3aH,5H,5aH,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-1-イル]-2-メチルヘプタン酸;ダファクロン酸A;(25S)-3-オキソ-5α-コレスタ-7-エン-26-酸;(25S)-Δ7-ダファクロン酸

英語名:: (25S)-Δ7-Dafachronic Acid

英語别名:: (25S)-Δ7-Dafachronic Acid;(25S)-Delta(7)-dafachronic acid;(5α,25S)-3-oxo-cholest-7-en-26-oicacid;Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)-;(25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid;(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid

CBNumber:: CB53152417

化学式:: C27H42O3

分子量:: 414.62

MOL File:: 949004-12-0.mol

物理性質

安全性情報

用途語

生産企業 14

ダファクロン酸A 物理性質

貯蔵温度 :: Store at -20°C

溶解性:: DMF: 5 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml

外見 :: A crystalline solid

色:: White to off-white

安全性情報

ダファクロン酸A 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

ダファクロン酸A 化学特性,用途語,生産方法

説明

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ⁷-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC₅₀ value of 23 nM. At 50 nM, (25S)-Δ⁷-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection.

定義

ChEBI: A Delta7-dafachronic acid that has S configuration at position 25 (the carbon attached to the carboxy group).

ダファクロン酸A 上流と下流の製品情報

原材料

準備製品

ダファクロン酸A 生産企業

Global( 14)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
amyjetsci	027-59626688 18771149750	sales@amyjet.com	China	3004	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
United States Biological	--	sales@advtechind.com	United States	6106	58

949004-12-0
(25S)-Δ7-Dafachronic Acid
(25S)-Delta(7)-dafachronic acid
(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid
Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)-
(25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid
(5α,25S)-3-oxo-cholest-7-en-26-oicacid
Δ7-ダファクロン酸
(2S,6R)-6-[(1R,3aR,5aS,9aS,9bR,11aR)-9a,11a-ジメチル-7-オキソ-1H,2H,3H,3aH,5H,5aH,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-1-イル]-2-メチルヘプタン酸
ダファクロン酸A
(25S)-3-オキソ-5α-コレスタ-7-エン-26-酸
(25S)-Δ7-ダファクロン酸