Fluclotizolam

 化学構造式
54123-15-8
CAS番号.
54123-15-8
化学名:
别名:
英語名:
Fluclotizolam
英語别名:
Fluclotizolam;2-chloro-4-(2-fluoro-phenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-chloro-4-(2-fluorophenyl)-9-methyl-
CBNumber:
CB55540779
化学式:
C15H10ClFN4S
分子量:
332.78
MOL File:
54123-15-8.mol

Fluclotizolam 物理性質

沸点 :
524.0±60.0 °C(Predicted)
比重(密度) :
1.57±0.1 g/cm3(Predicted)
貯蔵温度 :
-20°C
溶解性:
DMF: 5 mg/ml DMSO: 5 mg/ml DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
酸解離定数(Pka):
2.01±0.40(Predicted)
外見 :
A crystalline solid
極大吸収波長 (λmax):
241 nm
InChI:
InChI=1S/C15H10ClFN4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)17)10-6-12(16)22-15(10)21(8)13/h2-6H,7H2,1H3
InChIKey:
ZDYRCUZZLRLMHG-UHFFFAOYSA-N
SMILES:
N12C(C)=NN=C1CN=C(C1=CC=CC=C1F)C1C=C(Cl)SC=12

安全性情報

Fluclotizolam 化学特性,用途語,生産方法

説明

Fluclotizolam (Item No. 23524) is an analytical reference standard categorized as a thienotriazolodiazepine. This product is intended for research and forensic applications.

化学的特性

Flualprazolam (8-chloro-6-(2-fluorophenyl)-1-methyl-4H- [1,2,4]triazolo[4,3-a][1,4]benzodiazepine) is a triazolobenzodiazepine and is structurally similar to alprazolam. Flualprazolam is composed of a benzene ring fused to a seven-membered 1,4- diazepine ring. Flualprazolam also contains a fused triazolo ring. A methyl (-CH3) group is attached at the 1-position, a 2- fluorophenyl ring is attached at the 6-position, and a chlorine is attached at the 8-position of the triazolobenzodiazepine structure. Flualprazolam has a molecular formula of C17H12ClFN4 and a molecular weight of 326.76 g/mol.

来歴

Fluclotizolam is a thienotriazolodiazepine derivative which was first synthesised in 1979, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified in 2017.

使用

Fluclotizolam is one of the New Psychoactive Substancces (NPS).

規制状況(Regulatory Status)

Flualprazolam is not currently controlled under the Controlled Substances Act. At the 2020 Commission on Narcotic Drugs Sixty-third session, the Commission decided to include flualprazolam in Schedule IV of the 1971 Convention on Psychotropic Substance.
https://www.deadiversion.usdoj.gov

https://www.federalregister.gov

参考文献

1. Moosmann, B., and Auw?rter, V. New Psychoactive Substances. Handbook of Experimental Pharmacology. Designer benzodiazepines: Another class of new psychoactive substances 252, 383-410 (2018).

Fluclotizolam 上流と下流の製品情報

原材料

準備製品


  • 54123-15-8
  • 2-chloro-4-(2-fluoro-phenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
  • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 2-chloro-4-(2-fluorophenyl)-9-methyl-
  • Fluclotizolam
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