ランジオロール塩酸塩
ランジオロール塩酸塩 物理性質
- 融点 :
- 125.4°
- 貯蔵温度 :
- Refrigerator
- 溶解性:
- DMSO（微量）、エタノール（微量、超音波処理）
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
- 水溶解度 :
- H2O: 25mg/mL, clear
- InChIKey:
- DLPGJHSONYLBKP-WRNKUMIYNA-N
- SMILES:
- C(C1C=CC(OC[C@@H](O)CNCCNC(N2CCOCC2)=O)=CC=1)CC(=O)OC[C@@H]1COC(C)(C)O1.Cl |&1:7,29,r|
ランジオロール塩酸塩 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
L0296 |
ランジオロール塩酸塩 >98.0%(HPLC)(T)
Landiolol Hydrochloride
>98.0%(HPLC)(T) |
144481-98-1 |
50mg |
￥11800 |
2024-03-01 |
購入 |
|
東京化成工業
|
L0296 |
ランジオロール塩酸塩 >98.0%(HPLC)(T)
Landiolol Hydrochloride
>98.0%(HPLC)(T) |
144481-98-1 |
250mg |
￥40000 |
2024-03-01 |
購入 |
ランジオロール塩酸塩 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
効能
抗不整脈薬, β1遮断薬
商品名
オノアクト (小野薬品工業); コアベータ (小野薬品工業)
説明
Landiolol hydrochloride (14) was launched in Japan by
Ono for the treatment of intraoperative tachyarrhythmia. It
improves tachyarrhythmia by selectively blocking β1
receptors located mainly in the heart and by inhibiting the
action of catecholamine.
使用
Landiolol is an ultra-short acting beta blocker that is used to treat patients with cardiac arrhythmias and is also used to treat tachycardia during anasthesia.
臨床応用
Landiolol hydrochloride, a highly cardio-selective beta-1 blocker with an ultra-short-acting half-life of 4 minutes, is widely used in Japan under the brand name Onoact®. β-blockers is useful in preventing refractory and urgent fatal arrhythmia and tachycardia in chronic phase.Recently, European Union health authorities have approved usage under the name Rapibloc®. Landiolol was originally approved by Japan for treatment of intraoperative tachyarrhythmias and was later approved for tachycardia atrial fibrillation (AF) and atrial flutter (AFL) during left ventricular (LV) dysfunction in November 2013. More recently, landiolol expanded its utility into usage for fatal arrhythmia requiring emergency treatment in 20196 and is fast becoming a reliable therapeutic choice for management of arrhythmia in acute phase[1].
合成
The synthesis of landiolol
appeared in an earlier patent in 1990. Esterification of 3-
(4-hydroxyphenyl)propionic acid (141) with 2,2-dimethyl-
1,3-dioxolan-4-ylmethyl chloride (142) in DMSO gave
desired ester 143 in 57% yield. Treatment of phenol 143
with bromo epoxide 144 in the present of K2CO3 afforded
ether 145 in 76% yield. Epoxide 145 was then reacted with
free amine 146 via a neucleophilic ring opening process to
provide landiolol (14).
ランジオロール塩酸塩 上流と下流の製品情報
原材料
準備製品
ランジオロール塩酸塩 生産企業
Global( 215)Suppliers
144481-98-1(ランジオロール塩酸塩)キーワード:
- 144481-98-1
- [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate hydrochloride
- Landiolol hydrochloride
- Benzenepropanoic acid, 4-(2-hydroxy-3-((2-((4-morpholinylcarbonyl)amino)ethyl)amino)propoxy)-, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester, (S-(R*,R*))-, hydrochloride
- Ono 1101 hydrochloride
- -2,2-Dimethyl-1,3-dioxolan-4-yl)
- -2-hydroxy-3-((2-(morpholine-4-carboxamido)
- methyl 3-(4-((S)
- propanoate hydrochloride
- ((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate hydrochloride
- propoxy)
- Landiolol hydrochloride USP/EP/BP
- Landiolol hydrochloride salt
- Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1)
- Landiolol Hydrochloride
(Benzenepropanoic acid,
4-[(2S)-2-hydroxy-3-[[2-[(4-mo rpholinylcarbonyl)amino]ethyl] amino]propoxy]-,
[(4S)-2,2-dimethyl-1,3-dioxola n-4-yl]methyl ester, hydrochloride)
- Carteolol Impurity 2(Carteolol EP Impurity B )
- Landiolol hydrochloride, 10 mM in DMSO
- ((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((S)-2-hydroxy-3-((2-(morpholine-4-carboxamido)ethyl)amino)propoxy)phenyl)propanoate hydrochloride , Landiolol HCl
- andiolol hydrochloride
- ランジオロール塩酸塩
- ランジオロール塩酸塩 (JAN)
- オノアクト
- コアベータ
- 4-[(S)-2-ヒドロキシ-3-[[2-[(モルホリノカルボニル)アミノ]エチル]アミノ]プロポキシ]ベンゼンプロパン酸[(S)-2,2-ジメチル-1,3-ジオキソラン-4α-イル]メチル・塩酸
- 塩酸ランジオロール
- ランジオロール・塩酸塩