batroxostatin 化学特性,用途語,生産方法
酵素阻害剤
This cysteine-rich, 71-residue disintegrin (MW = 7602.46 g/mol; CAS 130357-67-4), from the snake Bothrops atrox (Barba amarilla) contains an RGD loop that facilitates high-affinity binding to integrins in a manner that inhibits ADP-induced platelet aggregation (IC50 = 133 nM), about 1000- times higher than that of Arg-Gly-Asp-Ser tetrapeptide. In addition, batroxostatin was about 400-times more potent than Arg-Gly-Asp-Ser at inhibiting melanoma cell adhesion to fibronectin. When covalently attached to plastic culture dishes, batroxostatin promoted adhesion of melanoma cells.
batroxostatin 上流と下流の製品情報
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