モノクローナル抗P38 MAPキナーゼ, 活性化型(二リン酸化型P38)抗体 マウス宿主抗体 化学特性,用途語,生産方法
使用
Anti-p38 MAP Kinase antibody has been used in western blotting (diluted 1:1000) using using NIH 3T3 mouse fibroblasts cell lysate and rat brain extract. It has also been used in microarray.
一般的な説明
P38 MAPK is a mitogen-activated protein kinase (MAPK) that belongs to serine/threonine protein kinases family and is activated in response to stress signals like- osmolarity changes, UV-irradiation, heat shock,cytokines and lipopolysaccharides (LPS). It mainly expresses in brain, muscle, thymus, spleen, heart, lung, kidney and fibroblasts.
Biochem/physiol Actions
Mitogen-activated protein kinases (MAP kinases, MAPKs) are a family of protein kinases which are considered to play a crucial role in signal transduction pathways in mammalian cells by leading mitogenic signals to their intracellular targets. MAP kinases regulate several cellular processes, such as proliferation, differentiation, response to stress and oncogenesis. p38 MAPK is activated in response to stress signals like- osmolarity changes, ultravoilet-irradiation, heat shock, cytokines and lipopolysaccharides (LPS). It is required for phosphorylation of MAPK-activated protein kinase 2 (MAPKAPK-2). Anti-p38 MAP Kinase antibody can be used to study the differential tissue expression, specific activation requirements and intracellular localization of MAP kinase isoforms in normal and neoplastic tissues.
モノクローナル抗P38 MAPキナーゼ, 活性化型(二リン酸化型P38)抗体 マウス宿主抗体 上流と下流の製品情報
原材料
準備製品