インジセトロン塩酸塩

インジセトロン塩酸塩 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

インジセトロン塩酸塩 化学特性,用途語,生産方法

効能

制吐薬, セロトニン5-HT3受容体拮抗薬

商品名

シンセロン (杏林製薬)

Originator

Nisshin (Japan)

brand name

Sinseron

合成

The synthesis is highlighted in the Scheme. Bromoacetaldehyde dimethyl acetal (44) was condensed with methylamine with KOH in refluxing ethyleneglycol for 3 hr to give 33% yield of bis(2,2-dimethoxyethyl)amine (45), which was cyclized with acetonedicarboxylic acid (46) and methylamine to generate 3,9-dimethyl-3,9-diazabicyclo- [3.3.1]nonan-7-one (47) in 12% yield. Compound 47 was reacted with hydroxylamine in refluxing pyridine and ethanol mixture to give corresponding oxime 48 in 88% yield, which was subsequently reduced with hydrogen over Raney Ni in hot ethanol in the presence of ammonium acetate at 50 kg/cm2 to give amine 49 in 89% yield. Compound 49 was condensed with 1H-indazole-3-carbonyl chloride (50) in pyridine with catalytic amount of DMAP to give crude indisteron free base, which was re-crystallized from chloroform/hexane to give indisteron free base as colorless crystals in 16% yield. Finally, the free base was treated with hydrogen chloride to give indisteron hydrochloride (VII).

インジセトロン塩酸塩 上流と下流の製品情報

原材料

準備製品

インジセトロン塩酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
HangZhou YuHao Chemical Technology Co., Ltd.	0571-82693216	info@yuhaochemical.com	China	2029	58
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Jinan Yaoyan Pharmaceutical Co., Ltd.		jnyaoyan@163.com	China	3069	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19105	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23962	58

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• 160472-97-9
• N-[(1S,5R)-7,9-dimethyl-7,9-diazabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide dihydrochloride
• Indisetron hydrochloride
• Indisetron Dihydrochloride
• N-[(1S,5R)-3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-yl]-1H-indazole-3-carboxamide
• N-[(1S,5R)-3,9-DIMETHYL-3,9-DIAZABICYCLO[3.3.1]NONAN-7-YL]-1H-INDAZOLE-3-CARBOXAMIDE;DIHYDROCHLORIDE
• N 3389T
• N3389T
• N-3389T
• Sinseron
• インジセトロン塩酸塩
• インジセトロン塩酸塩 (JAN)
• シンセロン
• N-[(1β,5β)-3,9-ジメチル-3,9-ジアザビシクロ[3.3.1]ノナン-7α-イル]-1H-インダゾール-3-カルボアミド・二塩酸塩
• 塩酸インジセトロン
• N-[(1R,5S)-3,9-ジメチル-3,9-ジアザビシクロ[3.3.1]ノナン-7α-イル]-1H-インダゾール-3-カルボアミド・2塩酸塩