2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)PROPYL DIHYDROGEN PHOSPHATE

2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)PROPYL DIHYDROGEN PHOSPHATE 価格

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2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)PROPYL DIHYDROGEN PHOSPHATE 化学特性,用途語,生産方法

説明

Fosfluconazole, a phosphate prodrug of fluconazole (96), was recently approved for intravenous use in Japan in October 2003. The drug was developed as a water-soluble prodrug by Pfizer as an enhancement to the injectable infusion formulation of fluconazole (96), a very potent antifungal agent, that could be used intravenously in bolus doses requiring smaller volumes of fluid and sodium.

合成

The disclosed manufacturing route of synthesis utilized fluconazole (96) as a precursor and was prepared in two steps using inexpensive starting materials. Fluconazole was dissolved in dichloromethane with pyridine and was treated sequentially with phosphorus trichloride at ¨C13??C and reacted at 13??C for 2 hr followed by an addition of benzyl alcohol at 14-16??C and reacted for 2 hrs at 10-15??C. The mixture was then cooled to 0??C and 30% hydrogen peroxide was added over three hours, maintaining the temperature below 20??C. After stirring the reaction at 20??C for 1hr, the intermediate 97 was isolated in 66% yield. Hydrogenation of the benzyl phosphate at 60 psi in water with 5% palladium on carbon gave the desired phosphate prodrug, fosfluconazole (XI) in 88% yield.

2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)PROPYL DIHYDROGEN PHOSPHATE 上流と下流の製品情報

原材料

準備製品

2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)PROPYL DIHYDROGEN PHOSPHATE 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11922	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 +86-13028896684;	sales@rrkchem.com	China	56752	58
Guangzhou Dreampharm Biotechnology Co., Ltd.	020-36607679 17825480238	3008233717@qq.com	China	9919	12
Jinan blalong chemical co. LTD	2710913286@.com	1513643261@qq.com	China	14246	58
Hubei Xinyang Medical Technology Co., Ltd	15347293736 15347293736	2853117764@qq.com	China	8327	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	021-51816796-820 13611835272	sales2@sunwaypharm.com	China	44458	58
Scinova Biotech(Guangzhou) Co., Ltd.	13268215580	scinova_sales@163.com	China	7023	58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd	18502726233; 18502726233	3641133981@qq.com	China	9705	58

1807913-50-3()キーワード:

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• 1807913-50-3
• FOSFLUCONAZOLE
• FLUCONAZOLE DIHYDROGEN PHOSPHATE
• Fosfluconazole Impurity 4
• 2-(2,4-Difluorophenyl)-1,3-di(1h-1,2,4-triazol-1-yl)propan-2-yl hydrogen phosphonate
• Phosphonic acid, mono[1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-(1H-1,2,4-triazol-1-ylmethyl)ethyl] ester
• FosflucozoleImpurity4
• 2-(2,4-DIFLUOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)PROPYL DIHYDROGEN PHOSPHATE