[2R,(-)]-3,9-ジヒドロ-8-メトキシ-9-メチル-2-イソプロピルフロ[2,3-b]キノリン-4(2H)-オン

[2R,(-)]-3,9-ジヒドロ-8-メトキシ-9-メチル-2-イソプロピルフロ[2,3-b]キノリン-4(2H)-オン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

[2R,(-)]-3,9-ジヒドロ-8-メトキシ-9-メチル-2-イソプロピルフロ[2,3-b]キノリン-4(2H)-オン 化学特性,用途語,生産方法

説明

A further alkaloid obtained from the bark of Lunasia costulata Miq., this base belongs to the furoquinolone group of alkaloids. It crystallizes as the monohydrate in colourless needles from AcOET, m.p. 95.5°C, losing H20 at lOOoC to give the anhydrous form with the above melting point. The alkaloid has [α]²⁸_D - 58° (EtOH). The following salts have been prepared: the hydrochloride, m.p. l64-5°C; [α]²⁸_D - 23° (H20); hydro bromide, m.p. 170-1 DC; hydriodide, m.p. 196-7°C; aurichloride, m.p. l76-7°C; picrate, m.p. 2l3-4°C and the methiodide, m.p. l30-loC (dec.). The last of these, on treatment with moist silver oxide produces an isomer of lunacrine, m.p. 85-6°C, this behaviour resembling that of certain other Rutaceous alkaloids, e.g. Skimmianine (q.v.). The (+)-form oflunacrine has m.p. 119-1200 C; [α]²⁵₅₈₉ + 66° and [α]²⁵₄₃₆+ 100°. This form also yields a crystalline perchlorate, m.p. 178-1800 C. The optically inactive form has been prepared as colourless crystals from AcOEt-pentane, m.p. l46-8°C.The alkaloid inhibits peristaltic movement of the isolated intestine. The median lethal dose of the hydrochloride is approximately 78.7 mgm per kilo when injected intravenously in mice. It is also stated to reduce arterial blood pressure in cats.

参考文献

Boorsma.,Meded. Lands. Plant., 31, 13, 126 (1899)
Boorsma.,Bull. Inst. Bot. Buit., No. 31, 8, 25 (1904)
Steldt, Chen., J. Amer. Pharm. Assoc., 32, 107 (1942)
Goodwin, Horning.,J. Amer. Chem. Soc., 81, 1908 (1959)
Clarke, Grundon., Chem. & Ind., 556 (1962)
Clarke, Grundon., J. Chem. Soc., 438 (1964)

[2R,(-)]-3,9-ジヒドロ-8-メトキシ-9-メチル-2-イソプロピルフロ[2,3-b]キノリン-4(2H)-オン 上流と下流の製品情報

原材料

準備製品

[2R,(-)]-3,9-ジヒドロ-8-メトキシ-9-メチル-2-イソプロピルフロ[2,3-b]キノリン-4(2H)-オン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度

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• 82-40-6
• [2R,(-)]-3,9-Dihydro-8-methoxy-9-methyl-2-isopropylfuro[2,3-b]quinolin-4(2H)-one
• [2R,(-)]-3,9-Dihydro-8-methoxy-9-methyl-2-isopropylfuro[2,3-b]quinoline-4(2H)-one
• Lunacrine
• C10711
• Furo[2,3-b]quinolin-4(2H)-one, 3,9-dihydro-8-methoxy-9-methyl-2-(1-methylethyl)-, (2R)-
• [2R,(-)]-3,9-ジヒドロ-8-メトキシ-9-メチル-2-イソプロピルフロ[2,3-b]キノリン-4(2H)-オン
• ルナクリン
• (2R)-8-メトキシ-9-メチル-2-(プロパン-2-イル)-2H,3H,4H,9H-フロ[2,3-b]キノリン-4-オン