S-(5'-アデノシル)-L-メチオニン=クロリド二塩酸塩 化学特性,用途語,生産方法
外観
白色~褐色、結晶~粉末
溶解性
水及びエタノールに溶け、アセトンに難溶である。
使用上の注意
アルゴン封入
説明
S-
(5''-
Adenosyl)-
L-
methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor produces S-
adenosyl-
L-
homocysteine . SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine. Cayman Chemical’s SAM has been purified to remove all S-
adenosylhomocysteine, a known inhibitor of most SAM-
dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-
methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.
使用
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-
O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.
一般的な説明
S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).
S-(5'-アデノシル)-L-メチオニン=クロリド二塩酸塩 上流と下流の製品情報
原材料
準備製品