3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone 価格 もっと(2)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	SML0822	≥98% (HPLC) YM-08 ≥98% (HPLC)	812647-88-4	5mg	￥29400	2024-03-01	購入
Sigma-Aldrich Japan	SML0822	≥98% (HPLC) YM-08 ≥98% (HPLC)	812647-88-4	25mg	￥88600	2024-03-01	購入

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone 化学特性,用途語,生産方法

Biochem/physiol Actions

YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials.

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone 上流と下流の製品情報

原材料

準備製品

3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19881	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Changzhou Bojia Biomedical Technology Co., Ltd.	2122619822	czbjpharma@126.com	China	18478	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	sales@szzxbio.com	China	2991	58

812647-88-4()キーワード:

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• 812647-88-4
• 3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone
• YM-08
• 4-Thiazolidinone, 3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-
• YM-08, blood-brain barrier permeable Hsp70 inhibitor