スジスマーゼ 化学特性,用途語,生産方法
外観
緑色澄明の液体
定義
本品は、好気性微生物から得られた金属酵素の混合物である。
性質
二量体または四量体．2O2- + 2H+ → H2O2 + O2 の不均化で活性酸素(O2-)を消去．Fe-SODとMn-SODの配列は相同，Cu/Zn-SODとは相同性なし
溶解性
水に溶ける。
解説
酸素分子の一電子還元で生じる超酸化物ラジカルの不均化反応を触媒する酵素．SODと略称される．活性中心の金属により，Cu，Zn含有酵素，Fe含有酵素，Mn含有酵素の3種類がある．嫌気性菌，好気性菌，原生動物，動物，植物などに分布する．生体内のこの酵素は活性酸素によって生じる組織の障害を防ぐ機能を有する．医薬品，化粧品，食品などへの利用が検討されている．
用途
突然変異と発癌のメカニズムの研究、医薬品(特に抗炎症剤)の開発研究、医薬品、食品、化粧品への添加剤の研究、臨床面の応用研究。
用途
突然変異と発癌のメカニズムの研究、医薬品(特に抗炎症剤)の開発研究、医薬品及び化粧品の添加剤。
化粧品の成分用途
還元剤、皮膚コンディショニング剤
使用上の注意
安定性50% Glycerol溶液は、4℃または-20℃で1年以上安定。
天然物の起源
Fe-SOD, Ps. aeruginosa：1～193；Mn-SOD, ウマ，マウス，ミトコンドリア：25-222；Cu/Zn-SOD, ラット分泌型：16～244
定義
Any of a type of antioxidant metalloenzymes that occur in aerobic and facultatitive bacteria and in eukarotes. They catalyze a reaction in which two molecules of the highly toxic, highly reactive, superoxide anion is converted into one molecule each of hydrogen peroxide and molecular oxygen.
利点
Based on the metal cofactors present in the active sites, Superoxide dismutases (SODs) can be classified into four distinct groups: Copper-Zinc-SOD (Cu, Zn-SOD), Iron SOD (Fe-SOD), Manganese SOD (Mn-SOD), and Nickel SOD. The enzyme can serve as an anti-inflammatory agent and can also prevent precancerous cell changes. SOD is used in cosmetics and personal care products as an anti-aging ingredient and antioxidant due to its ability to reduce free radical damage to the skin, therefore preventing wrinkles, fine lines, and age spots, and it also helps with wound healing, softens scar tissue, protects against UV rays, and reduces other signs of aging. It has been reported that SOD has an important link in several human health problems including RBC-related disorders, cystic fibrosis (CF), postcholecystectomy pain syndrome, malignant breast disease, steroid-sensitive nephrotic syndrome, amyotrophic lateral sclerosis, neuronal apoptosis, AIDS, and cancer. In many animal models having myocardial ischemia-reperfusion injury, inflammation, cerebral ischemia-reperfusion injury, etc., SOD enzymes are found to be very effective. Furthermore, a strong association between the activity of SOD and Alzheimer's disease has been suggested by some researchers[1-2].
一般的な説明
Superoxide dismutases are a group of low molecular weight metalloproteins present in all aerobic cells of plants, animals and micro-organisms. They provide protection against damaging reactions with the superoxide radical anion (O2-) by catalyzing its disproportionation into oxygen and hydrogen peroxide.
一般的な説明
Superoxide dismutase (SOD) is the only antioxidant enzyme that scavenges the superoxide anion by converting this free radical to oxygen and hydrogen peroxide, thus preventing peroxynitrite production and further damage. Superoxide dismutase is extensively researched and used in anti-inflammatory, antitumor, radiation protection, and antisenility applications.
純化方法
The dismutase is purified by DEAE-Sepharose and copper chelate affinity chromatography. The preparation is homogeneous by SDS-PAGE, by analytical gel filtration chromatography and by isoelectric focusing.
スジスマーゼ 上流と下流の製品情報
原材料
準備製品