サルポグレラート塩酸塩(異性体混合物)
サルポグレラート塩酸塩(異性体混合物) 物理性質
- 融点 :
- 145-148°C
- 貯蔵温度 :
- Inert atmosphere,2-8°C
- 溶解性:
- 脱イオン水: ≥5mg/mL
- 外見 :
- 個体
- 色:
- White to off-white
- InChIKey:
- POQBIDFFYCYHOB-UHFFFAOYSA-N
- CAS データベース:
- 135159-51-2(CAS DataBase Reference)
サルポグレラート塩酸塩(異性体混合物) 価格
もっと(10)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC3739 |
Sarpogrelate hydrochloride |
135159-51-2 |
10mg |
￥44000 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC3739 |
Sarpogrelate hydrochloride |
135159-51-2 |
50mg |
￥200000 |
2018-12-26 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
46191-1A |
Sarpogrelate hydrochloride |
135159-51-2 |
1g |
￥76890 |
2024-07-01 |
購入 |
|
Sigma-Aldrich Japan
|
S5451 |
塩酸サルポグレラート ≥98% (HPLC)
Sarpogrelate hydrochloride ≥98% (HPLC) |
135159-51-2 |
5mg |
￥16800 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
S5451 |
塩酸サルポグレラート ≥98% (HPLC)
Sarpogrelate hydrochloride ≥98% (HPLC) |
135159-51-2 |
25mg |
￥52700 |
2024-03-01 |
購入 |
サルポグレラート塩酸塩(異性体混合物) 化学特性,用途語,生産方法
外観
白色～ほとんど白色、結晶～粉末
溶解性
水に可溶
用途
5-HT2A レセプター選択的なア
ンタゴニストです。5-HT2A レセプターを阻害
することにより、血小板凝集抑制作用を示し
ます。
効能
抗凝固薬, 血小板凝集抑制薬, セロトニン5-HT2受容体拮抗薬
商品名
アンプラーグ (田辺三菱製薬)
説明
Sarpogrelate hydrochloride, a potent and selective serotonin 5-HT
2 receptor
antagonist, was launched in Japan as an antithrombotic. It exhibits inhibition of ex vivo
platelet aggregation stimulated by serotonin in combination with collagen and suppression of
blood vessel constriction mediated by 5-HT
2 in vitro. Its antithrombotic effects have been
demonstrated in several in vivo experimental models including reduction of the mortality rate in
acute pulmonary thromboembolic disease, arterial thrombosis, and peripheral obstructive
disease. Sarpogrelate has been shown to be especially useful as an antiplatelet agent for
patients with Type 2 diabetes mellitus, in whom 5-HT
2mediated amplification of collageninduced
platelet aggregation is significantly increased.
化学的特性
White Solid
使用
Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist
ress-induced hemolysis.
生物活性
Selective 5-HT 2A receptor antagonist (pK i values are 8.52, 7.43 and 6.57 for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Displays selectivity over 5-HT 1 , 5-HT 3 , 5-HT 4 H 1 , H 2 , M 3 , α 1 -adrenergic, α 2 -adrenergic and β -adrenergic receptors. Displays cardioprotective activity in vivo .
サルポグレラート塩酸塩(異性体混合物) 上流と下流の製品情報
原材料
準備製品
サルポグレラート塩酸塩(異性体混合物) 生産企業
Global( 264)Suppliers
サルポグレラート塩酸塩(異性体混合物) スペクトルデータ(1HNMR)
135159-51-2(サルポグレラート塩酸塩(異性体混合物))キーワード:
- 135159-51-2
- Sarpogrelate-D3 HCl
- Anplag
- Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride (9CI)
- Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride, (+-)-
- MCI 9042
- 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid hydrochloride
- 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxo-butanoic acid hydrochloride
- 4-[1-(dimethylaminomethyl)-2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethoxy]-4-keto-butyric acid hydrochloride
- Succinicacidmono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)ethyl]phenoxy)ethyl)esterhydrochloride
- Butanedioic acid 1-[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester hydrochloride
- Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)et hyl]phenoxy)ethyl) ester hydro
- SARPOGRELATE HYDROCHLORIDE
- (+/-)-2-(dimethylamino)-1-{[o-(m-methoxyphenethyl)phenoxy]methyl}ethyl hydrogen succinate hydrochloride
- 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}pr
- Sarpogrelate Hydrochloride intermediate
- 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid hydrochloride (1:1)
- Sarpogrelate hydrochloride, >=99%
- 4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride
- Butanedioic acid, mono[2-(dimethylamino)-1-[[
- ANPLAG;MCI 9042;MCI9042;MCI-9042
- Sarpogrelate Hydrochloride
（mixture of isomers）
- Sarpogrelate Hydrochloride RS
- Sarpogrelate hydrochloride USP/EP/BP
- Sarpogrelate hydroch
- (+/-)-2-(dimethylamino)-1-{[o-(m-methoxyphenethyl)phenoxy]methyl}ethyl hydrogen succinate hydrochloride
- Sarpogrelate HydrochlorideQ: What is
Sarpogrelate Hydrochloride Q: What is the CAS Number of
Sarpogrelate Hydrochloride Q: What is the storage condition of
Sarpogrelate Hydrochloride
- SARPOGRELATE HCL
- LS 187,118
- LS187,118
- LS-187,118
- サルポグレラート塩酸塩(異性体混合物)
- サルポグレラート塩酸塩
- 塩酸サルポグレラート
- サルポグレラート塩酸塩 (JP17)
- こはく酸1-[1-ジメチルアミノメチル-2-[2-[2-(3-メトキシフェニル)エチル]フェノキシ]エチル]・塩酸塩
- 塩酸サルボグレラート
- アンプラーグ
- サルポグレラート・塩酸塩