AK-2292 化学特性,用途語,生産方法
説明
AK-2292 is a potent and highly selective STAT5 PROTAC degrader. AK-2292 induces STAT5A/B protein degradation in vitro and in vivo, as well as excellent selectivity for all other STAT proteins and more than 6,000 non-STAT proteins, resulting in the selective inhibition of STAT5 activity in the cell. AK-2292 effectively induces STAT5 degradation in normal mouse tissues and human chronic myeloid leukaemia (CML) mouse xenografts. It also effectively inhibits the growth of acute myeloid leukaemia (AML) cell lines.
化学的特性
Off-white to light yellow Solid
AK-2292 上流と下流の製品情報
原材料
準備製品