AZD7762
AZD7762 物理性質
- 沸点 :
- 547.6±50.0 °C(Predicted)
- 比重(密度) :
- 1.38
- 貯蔵温度 :
- -20°
- 溶解性:
- DMSO に可溶 (少なくとも 25 mg/ml まで)。
- 外見 :
- 個体
- 酸解離定数(Pka):
- 9.06±0.20(Predicted)
- 色:
- 黄色または茶色
- 安定性::
- -20°C の DMSO 溶液で最大 3 か月間保存できます。
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCA808125 |
AZD7762
AZD 7762 |
860352-01-8 |
10mg |
¥45900 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCA808125 |
AZD7762
AZD 7762 |
860352-01-8 |
25mg |
¥91600 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCA808125 |
AZD7762
AZD 7762 |
860352-01-8 |
100mg |
¥244800 |
2023-06-01 |
購入 |
AZD7762 化学特性,用途語,生産方法
説明
Actively proliferating cells experience blocks at certain checkpoints in the cell cycle when DNA damage is detected. These checkpoints allow for DNA damage repair before further cell cycle progression. Targeting signaling pathways to selectively inhibit repair at these checkpoints in tumor cells is of considerable interest to cancer therapeutics. AZD 7762 selectively inhibits the activity of checkpoint kinases (Chk) 1 and Chk2 (IC
50s = 5 nM) by competitively and reversibly binding their respective ATP-
binding sites (K
i = 3.6 nM for Chk1). AZD 7762 abrogates DNA damage-
induced S and G
2 checkpoints with an EC
50 value of 10 nM and potentiates the efficacy of DNA-
damage repair prohibitive agents, gemcitabine and topotecan, both
in vitro and in various tumor xenografts by modulating downstream checkpoint pathway proteins.
使用
AZD 7762 is studied as an cancer therapeutic agent due to its selective inhibitory activities towards checkpoint kinases, chk1 and chk2 by reversibly binding their respective ATP-binding sites within
tumor cells. Recent research has also indicated AZD 7762 to possess enhancing effects towards other chk1 inhibitor lethality in glioblastoma cells.
AZD7762 上流と下流の製品情報
原材料
準備製品
AZD7762 生産企業
Global( 127)Suppliers
AZD7762 スペクトルデータ(1HNMR、MS)
860352-01-8(AZD7762)キーワード:
- 860352-01-8
- 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide
- 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide
- AZD 7762
- White solid
- 1-(2-((S)-piperidin-3-ylcarbamoyl)-5-(3-fluorophenyl)thiophen-3-yl)urea
- 5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide AZD 7762
- AZD 7762
5-(3-Fluorophenyl)-3-ureidothiophene-N-[(S)-piperidin-3-yl]-2-carboxamide
- (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide
- AZD7762; AZD-7762
- CS-314
- 2-Thiophenecarboxamide, 3-[(aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-
- 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-Thiophenecarboxamide USP/EP/BP
- (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide hydrochloride
- 3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide
- AZD-7762 Chk Inhibitor
- AZD7762
- N-[(3S)-ピペリジン-3-イル]-3-ウレイド-5-(3-フルオロフェニル)チオフェン-2-カルボアミド
- 3-(カルバモイルアミノ)-5-(3-フルオロフェニル)-N-[(3S)-ピペリジン-3-イル]チオフェン-2-カルボキサミド