Baricitinib phosphate salt
Baricitinib phosphate salt 物理性質
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- insoluble in EtOH; insoluble in H2O; ≥172.6 mg/mL in DMSO
- 外見 :
- 白い粉。
- 色:
- White to yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
Baricitinib phosphate salt 価格
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Baricitinib phosphate salt 化学特性,用途語,生産方法
使用
Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.
in vitro
In cell-based assays, Baricitinib phosphate proves to be a potent inhibitor of JAK signaling and function. In PBMCs, Baricitinib inhibits IL-6-stimulated phosphorylation of the canonical substrate STAT3 (pSTAT3) and subsequent production of the chemokine MCP-1 with IC50 values of 44 nM and 40 nM, respectively. In isolated naive T-cells, INCB028050 also inhibits pSTAT3 stimulated by IL-23 (IC50=20 nM). Importantly, this inhibition prevented the production of two pathogenic cytokines (IL-17 and IL-22) produced by Th17 cells-a subtype of helper T cells with demonstrable inflammatory and pathogenic properties-with an IC50 value of 50 nM. In stark contrast, the structurally similar but ineffective JAK1/2 inhibitors INCB027753 and INCB029843 has no significant effect in any of these assays systems when tested at concentrations up to 10 μM.
Baricitinib phosphate salt 上流と下流の製品情報
原材料
準備製品
Baricitinib phosphate salt 生産企業
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1187595-84-1()キーワード:
- 1187595-84-1
- 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile phosphate
- Baricitinib phosphate salt
- INCB-28050
- INCB-28050; LY3009104
- Baricitinib (phosphate)
- [1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl]acetonitrile phosphate
- INCB424-Analogue (INCB-28050)
- INCB-028050;LY-3009104;INCB 028050;LY 3009104;INCB028050;LY3009104
- Baricitinib phosphate (LY3009104 phosphate
- BARICITINIB PHOSPHATE (LY3009104 PHOSPHATE; INCB028050 PHOSPHATE)
- INCB028050 phosphate)
- LY-3009104 phosphate
- Baricitinib phosphate (LY-3009104, INCB-028050, Olumiant)