チモシンΑ1

チモシンΑ1 化学構造式
62304-98-7
CAS番号.
62304-98-7
化学名:
チモシンΑ1
别名:
チモシンΑ1;チモシンΑ-1;チモシンα1【ox】;チモシンα1【ヒト】
英語名:
Thymosin α1
英語别名:
THYMOSIN A1;THYMOSIN ALPHA 1;ZADAXIN;Thymosin α1 Acetate;Thymosin α1 Acetate;Thymosin α1;Thymosin Alpha;THYMOSIN APHA 1;Thymosina1Acetate;ThyMosins alpha 1
CBNumber:
CB7678989
化学式:
C129H215N33O55
分子量:
3108.32
MOL File:
62304-98-7.mol

チモシンΑ1 物理性質

沸点 :
2899.7±65.0 °C(Predicted)
比重(密度) :
1.360±0.06 g/cm3(Predicted)
貯蔵温度 :
−20°C
溶解性:
滅菌した 18MΩ-cm H2O で凍結乾燥したチモシン a1 を 100 μg/ml 以上の濃度で再構成し、次に他の水溶液に希釈することをお勧めします。
外見 :
A crystalline solid
色:
滅菌ろ過された白色の凍結乾燥(凍結乾燥)粉末。
シーケンス:
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
安定性::
凍結乾燥サイモシン a1 は、室温で 3 週間安定で、-18°C 以下で乾燥保存できます。再構成後、サイモシン a1 は 4°C で 2 ~ 7 日間保存でき、-18°C 以下で使用できます。
長期保存が必要な場合は、キャリアタンパク質 (0.1% HSA または BSA) を添加することをお勧めします。 < br/>凍結融解は避けてください。
InChIKey:
NZVYCXVTEHPMHE-WTRFZTBJNA-N

安全性情報

WGK Germany  3

チモシンΑ1 価格 もっと(9)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTT3096 チモシンα-1
Thymosin α-1
62304-98-7 50mg ¥345800 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01BCS4031308 チモシンα1
Thymosin alpha1
62304-98-7 1mg ¥79000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01BCS4031308 チモシンα1
Thymosin alpha1
62304-98-7 5mg ¥315000 2024-03-01 購入
Sigma-Aldrich Japan T3410 ≥90% (HPLC)
Thymosin α1 ≥90% (HPLC)
62304-98-7 0.5mg ¥101000 2024-03-01 購入
Sigma-Aldrich Japan T3410 ≥90% (HPLC)
Thymosin α1 ≥90% (HPLC)
62304-98-7 0.1mg ¥28900 2023-06-01 購入

チモシンΑ1 化学特性,用途語,生産方法

説明

Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo. It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator (CFTRF508del/F508del) mouse model of cystic fibrosis and chronic A. fumigatus infection.

使用

Zadax-in (SciClone).
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function.
Immune enhancing peptide
Helps prevent infections such as the common cold or the flu and diseases
Reduces inflammation in the body
Aids in the removal of acute or chronic infections
Has antibacterial, antiviral, and antifungal properties
Supports the eradication of unhealthy cells
Protects your cells against oxidative stress and damage
Inhibits viral replication
Improve symptoms associated with chronic fatigue
Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections.
https://www.ncbi.nlm.nih.gov

生物学の機能

Thymalfasin is a synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha. Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity.
https://www.prospecbio.com

チモシンΑ1 上流と下流の製品情報

原材料

準備製品


チモシンΑ1 生産企業

Global( 346)Suppliers
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Cellmano Biotech Limited
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Zhuzhou New Peptides Tech Co.,Ltd.
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sales@goodpeptides.com China 56 58
BOC Sciences
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Ethan@dornechem.com China 3102 58
Shanghai Yunao International Trade Co., Ltd
+8617621705551
asdf@shanghaihg.cn China 264 58

62304-98-7(チモシンΑ1)キーワード:


  • 62304-98-7
  • Thymosina1Acetate
  • Thymosin α1, Thymalfasin
  • ACETYL-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN
  • AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
  • AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN
  • AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN-OH
  • THYMOSIN A1 BOVINE
  • THYMOSIN ALPHA1 BOVINE
  • THYMOSIN APHA 1
  • Thymosin α 1 Acetate(Thymalfasin)
  • thymosin α1 bovine
  • AC-SER-ASP-ALA-ALA-VAL-ASP-THR-SER-SER-GLU-ILE-THR-THR-LYS-ASP-LEU-LYS-GLU-LYS-LYS-GLU-VAL-VAL-GLU-GLU-ALA-GLU-ASN: AC-SDAAVDTSSEITTKDLKEKKEVVEEAEN
  • Thymosinα1 bovine,Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
  • ThyMosins alpha 1
  • Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH acetate salt
  • Thymalfasin/Thymosin α1 Acetate
  • Thymosin α1 (cattle)
  • Thymalfasin (Thymosin α1)
  • Thymosin α1
  • Thymosin α1 (human, mouse, rat, bovine)
  • Thymosin α1(Thymalfasin)
  • Injectable Lyophillzed Powder Peptides Peptide Thymosin Acetate/Thymosin Alpha-1/Thymosin 10mg/Vial
  • Thymosin α1 USP/EP/BP
  • Thymosin αAcetate salt
  • Thymalfasin Acetate salt
  • Thymalfasin/Thymosin α1 Acetate
  • alpha 1 Thymosin α1
  • THYMOSIN A1
  • THYMOSIN ALPHA 1
  • ZADAXIN
  • チモシンΑ1
  • チモシンΑ-1
  • チモシンα1【ox】
  • チモシンα1【ヒト】
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