Bis(maltolato)oxovanadium(IV)
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- CAS番号.
- 38213-69-3
- 化学名:
- 别名:
- 英語名:
- Bis(maltolato)oxovanadium(IV)
- 英語别名:
- BMOV;BIS(MALTOLATO)OXOVANADIUM;BIS(MALTOLATO)OXOVANADIUM(IV);oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate);(SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM;Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-;Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium;type-2,Phosphatase,inhibit,Bis(maltolato)oxovanadium(IV),SHP2,Inhibitor,phenotype,metabolic,SHP-1,HCPTPA,uptake,glucose,HPTPβ,insulin,PTP,PTP1B,diabetes
- CBNumber:
- CB8113685
- 化学式:
- C12H10O7V
- 分子量:
- 317.15
- MOL File:
- 38213-69-3.mol
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Bis(maltolato)oxovanadium(IV) 物理性質
- 融点 :
- >300°C (dec.)
- 貯蔵温度 :
- Refrigerator
- 溶解性:
- DMSO（微量）、メタノール（微量）、水（微量）
- 外見 :
- 粉
- 色:
- 黄色から灰色、茶色
- LogP:
- 0.079 (est)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| 絵表示（GHS） |
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| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| 注意書き |
| P301+P310 |
飲み込んだ場合：直ちに医師に連絡すること。 |
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Bis(maltolato)oxovanadium(IV) 価格
もっと(1)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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Sigma-Aldrich Japan
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SML1079 |
≥95% (elemental analysis)
BMOV ≥95% (elemental analysis) |
38213-69-3 |
10mg |
￥10600 |
2024-03-01 |
購入 |
Bis(maltolato)oxovanadium(IV) 化学特性,用途語,生産方法
化学的特性
Dark Purple Solid
使用
It is a potent insulin mimic. Results showed that
a promising outlook as an oral glucose-lowering drug.
応用例（製薬）
Bis(maltolato)oxovanadium (BMOV) has proven itself as a successful antidiabetic agent when tested in animalmodels. Nevertheless, only
very little is known about its mode of action. It is believed that BMOV acts as a competitive and reversible
inhibitor of the enzyme protein tyrosine phosphatase (PTP).
As previously mentioned, BMOV is believed to be a potent and competitive inhibitor of the PTP1B activity
and additionally seem to support the autophosphorylation of the insulin receptor leading to an increased sensitivity
towards insulin. Research has shown that varying the organic ligand has an influence on the effectiveness
and bioavailability of the resulting vanadium compound. It is believed that factors such as absorption, tissue
uptake and distribution are affected most. Interestingly enough, X-ray crystal data of PTP1B soaked with
BMOV showed only vanadate [V(+V)O
43?] at the active site. This would emphasise that the organic ligands
are only carriers of the active compound and play no role in the enzyme inhibition itself. Furthermore,
in aqueous solution, V(IV) is rapidly and reversibly oxidised to V(V), supporting the possible formation of
vanadate.
Bis(maltolato)oxovanadium(IV) 上流と下流の製品情報
原材料
準備製品
Bis(maltolato)oxovanadium(IV) 生産企業
Global( 78)Suppliers
38213-69-3()キーワード:
- 38213-69-3
- BMOV
- BIS(MALTOLATO)OXOVANADIUM(IV)
- BIS(MALTOLATO)OXOVANADIUM
- (SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM
- oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate)
- Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-
- Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium
- type-2,Phosphatase,inhibit,Bis(maltolato)oxovanadium(IV),SHP2,Inhibitor,phenotype,metabolic,SHP-1,HCPTPA,uptake,glucose,HPTPβ,insulin,PTP,PTP1B,diabetes