2,2-ジフェニルプロピオン酸2-ジエチルアミノエチル 化学特性,用途語,生産方法
Originator
Aprofene,ZYF Pharm Chemical
Manufacturing Process
32 parts of α,α-diphenylpropionic acid chloride (made from diphenylpropionic
acid and thionyl chloride, B.P./12 mm 170°C) are mixed with 50 parts of
diethylaminoethanol. The mixture is heated for two hours to 150°-160°C. It is
then suspended in dilute hydrochloric acid. The solution is treated with ether.
After separation of the aqueous solution, the base is precipitated with sodium
hydroxide solution and suspended in ether.
After removal of the ether by distillation, the residue is distilled in a vacuum.
α,α-Diphenylpropionic acid β-diethylaminoethyl ester is obtained as a thick oil
by distilling under 2 mm pressure at 180°-185°C. It is readily soluble in
diluted acids.
Therapeutic Function
Spasmolytic
2,2-ジフェニルプロピオン酸2-ジエチルアミノエチル 上流と下流の製品情報
原材料
準備製品