パニツムマブ(遺伝子組換え) 化学特性,用途語,生産方法
説明
Panitumumab is a recombinant, fully human IgG2 kappa monoclonal antibody
that is highly selective for the epidermal growth factor receptor (EGFR),
and it is indicated for the treatment of EGFR-expressing, metastatic colorectal
carcinoma (mCRC) with disease progression on or following fluoropyrimidine-,
oxaliplatin-, and irinotecan-containing chemotherapy regimens. Overexpression
of EGFR is detected in many human cancers, including those of the colon and
rectum. Panitumumab blocks the binding of ligands such as epidermal growth
factor (EGF) and transforming growth factor (TGF-a) to various EGFR-expressing
cell lines, which results in inhibition of EGF-dependent tumor cell activation,
induction of apoptosis, and decreased pro-inflammatory cytokine and vascular
growth factor production. In vitro, panitumumab binds EGFR with high affinity
(KD ? 50pM; IC50 ? 3 nM) in human cervical epidermal cell line A-431.
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使用
Antineoplastic.
パニツムマブ(遺伝子組換え) 上流と下流の製品情報
原材料
準備製品