1-(トリメチルシリル)-2-プロパノン 化学特性,用途語,生産方法
物理的性質
Clear liquid; bp 74 °C/96 mmHg; d 0.8274 g cm?3
(26 °C), n26/D 1.4188.
使用
Trimethylsilylacetone reacts with Grignard or organolithium reagents to provide, after
elimination, 2-substituted 2-propenes; in combination with
fluoride ion, gives chemistry of the corresponding enolate ion; can direct electrophilic substitution to either side of the carbonyl group, participating in (but not limited to) reactions: Preparation of 2-substituted α-Alkenes, Reaction with Electrophiles, Reaction with Fluoride Ion, Reaction with Strong Bases, etc.
製造方法
The best procedure for the preparation
of trimethylsilylacetone is the reaction of trimethylsilylmethylmagnesium
chloride or bromide with acetic anhydride.5
Other useful preparative methods for α-trimethylsilyl ketones
involve the reaction of trimethylsilylmethylmagnesium chloride
with acid chlorides,6 or with aldehydes followed by oxidation
of the resulting β-hydroxysilane to the ketone.2e When the
trialkylsilyl group is very large, particularly the triisopropylsilyl
group, a rearrangement from the silyl enol ether to the α-silyl
ketone is possible.
1-(トリメチルシリル)-2-プロパノン 上流と下流の製品情報
原材料
準備製品