抗血管内皮増殖因子受容体-2抗体 ヤギ宿主抗体 化学特性,用途語,生産方法
使用
Anti-Vascular Endothelial Growth Factor Receptor 2 antibody may be used in immunoblotting at a working concentration of 0.1-0.2 μg/ml. For flow cytometry the recommended concentration is 3-10 μg/ml. The immunohistochemistry of cells and tissues, a working concentration of 5-15 μg/ml may be used. For neutralization reactions, ND50 of 0.1-0.3 μg/ml is recommended.
一般的な説明
Vascular endothelial growth factors receptors (VEGF Rs) are receptor tyrosine kinases that bind to VEGF that plays important role in embryonic vasculogenesis, angiogenesis and homeostasis. VEGF R2 has the ability to form heterodimers with VEGF R1 and VEGF R3. The binding of VEGF to VEGF R2 results in activation of tyrosine amino acids of the cytoplasmic tail of the receptor. This interaction results in the activation of MAPK, PI3K, PKC, FAK and Src kinase pathways. The biological roles of VEGF R2 include in epithelial cell growth, proliferation, survival, migration and vascular permeability and angiogenesis. Due to its role in promoting migration and angiogenesis, VEGF R2 has been implicated in breast and prostate cancer
Anti-Vascular Endothelial Growth Factor Receptor-2 recognizes mouse VEGF R2.
抗血管内皮増殖因子受容体-2抗体 ヤギ宿主抗体 上流と下流の製品情報
原材料
準備製品