5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

919486-40-1

CAS番号.: 919486-40-1

化学名:

别名:

英語名:: 5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

英語别名:: CS-2440;AS 1517499;AS-1517499;AS 1517499;AS-1517499; AS1517499; AS 1517499;919486-40-1;STAT,AS-1517499,inhibit,AS 1517499,AS1517499,Inhibitor;4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide;5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

CBNumber:: CB82624615

化学式:: C20H20ClN5O2

分子量:: 397.86

MOL File:: 919486-40-1.mol

MSDS File:: SDS

物理性質

安全性情報

価格2

用途語

生産企業 54

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- 物理性質

貯蔵温度 :: 2-8°C

溶解性:: DMF: 25mg/mL; DMF:PBS (pH 7.2) (1:6): 0.14mg/mL; DMSO: 15mg/mL; Ethanol: 5mg/mL

外見 :: 粉

色:: 白からベージュ

安全性情報

リスクと安全性に関する声明
危険有害性情報のコード(GHS)

絵表示（GHS）

注意喚起語

警告

危険有害性情報

コード	危険有害性情報	危険有害性クラス	区分	注意喚起語	シンボル	P コード
H302	飲み込むと有害	急性毒性、経口	4	警告		P264, P270, P301+P312, P330, P501

注意書き

P280	保護手袋/保護衣/保護眼鏡/保護面を着用すること。
P305+P351+P338	眼に入った場合：水で数分間注意深く洗うこと。次にコンタクトレンズを着用していて容易に外せる場合は外すこと。その後も洗浄を続けること。

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- 価格もっと(2)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	SML1906	≥98% (HPLC) AS1517499 ≥98% (HPLC)	919486-40-1	5mg	￥25800	2024-03-01	購入
Sigma-Aldrich Japan	SML1906	≥98% (HPLC) AS1517499 ≥98% (HPLC)	919486-40-1	25mg	￥82900	2024-03-01	購入

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- 化学特性,用途語,生産方法

説明

AS1517499 is a STAT6 inhibitor (IC₅₀ = 21 nM in a reporter assay). It inhibits IL-4-induced Th2 differentiation (IC₅₀ = 2.3 nM), but not IL-12-induced Th1 differentiation, of mouse spleen T cells. AS1517499 (10 mg/kg) inhibits bronchial smooth muscle hyperresponsiveness and IL-13 production in ovalbumin-sensitized mice when administered one hour prior to antigen exposure. It inhibits STAT6 phosphorylation and thyroid epithelial cell (TEC) hyperplasia and decreases serum levels of 3,3'',5-triiodo-L-thyronine (T3; ) and thyroxine (T4) in a mouse model of Graves'' disease when administered at a dose of 10 mg/kg per day. AS1517499 (20 mg/kg twice weekly) also inhibits tumor growth and liver metastasis in a murine orthotopic 4T1 mammary carcinoma model.

Biochem/physiol Actions

AS1517499 moderately inhibits the expression of RhoA (ras homolog family member A). Overexpression of RhoA protein is associated with allergic bronchial asthma.

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- 上流と下流の製品情報

原材料

準備製品

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]- 生産企業

Global( 54)Suppliers

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Wuhan TCASChem Technology Co., Ltd.	027-027-86697669 13986148687	sales@tcaschem.com	China	3888	55
Nanjing JinruiJiuAn Biotechnology Co., Ltd.	025-58196018 800028039	sales@fartop.net	China	2231	55

919486-40-1
5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-
AS 1517499
4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide
AS-1517499;AS 1517499
AS-1517499; AS1517499; AS 1517499;919486-40-1
CS-2440
STAT,AS-1517499,inhibit,AS 1517499,AS1517499,Inhibitor